Effect of fentanyl target-controlled infusions on isoflurane minimum anaesthetic concentration and cardiovascular function in red-tailed hawks (Buteo jamaicensis)
Effect of fentanyl target-controlled infusions on isoflurane minimum anaesthetic concentration and cardiovascular function in red-tailed hawks (Buteo jamaicensis)
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DOI：
10.1111/j.1467-2995.2011.00627.x
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发表时间：
2011-07-01
影响因子：
1.7
通讯作者：
Kass, Philip H.
中科院分区：
文献类型：
--
作者：
Pavez, Juan C.;Hawkins, Michelle G.;Kass, Philip H.
目的 确定芬太尼三种不同目标血浆浓度对红尾鹰异氟醚最低麻醉浓度 (MAC) 的影响以及对血流动力学特征的影响。研究设计实验研究。动物群体六只健康成年红尾鹰（Buteo jamaicensis），性别未知，体重（平均值+/-SD）为 1.21+/-0.15 kg。方法本研究分两个阶段进行阶段。在第一阶段，通过面罩用氧气中的异氟醚诱导麻醉，并通过贝恩回路用氧气中的异氟醚维持麻醉。仪器使用括号法和超最大电刺激对每只动物的异氟烷 MAC 进行基线测定。然后将呼气末异氟烷浓度 (E'Iso) 设置为 0.75 x MAC，并在适当的平衡期后静脉内 (IV) 静脉注射 (IV) 推注芬太尼 (20 μ g kg(-1))，以确定芬太尼在异氟烷麻醉的红尾鹰中的药代动力学。在第二阶段，以类似的方式诱导麻醉，并且每个个体的 E'Iso 设置为 0.75 x MAC。静脉输注芬太尼以达到 8 至 32 ng mL(-1) 之间的目标血浆浓度。在每个芬太尼血浆浓度。确定了异氟烷和心血管变量的 MAC。使用重复测量方差分析对数据进行分析。结果平均+/-SD芬太尼血浆浓度和异氟醚MAC为0+/-0、8.51+/-4、14.85+/-4.82和29.25+/-11.52ngmL(-1)、以及2.05+/-0.45%、1.42+/-0.53%。对于 0、8、16 和 32 ng mL(-1) 的目标浓度，分别为 1.14 +/- 0.31% 和 0.93 +/- 0.32%。在这些浓度下，芬太尼显着 (p = 0.0016) 使异氟烷 MAC 分别降低 31%、44% 和 55%。剂量对心率、收缩压、舒张压或平均动脉压没有显着影响。 结论和临床相关性 芬太尼使异氟烷 MAC 产生剂量相关的降低，对红尾鹰测量的心血管参数影响最小。
Objective To determine the impact of three different target plasma concentrations of fentanyl on the minimum anaesthetic concentration (MAC) for isoflurane in the red-tailed hawk and the effects on the haemodynamic profile.Study design Experimental study.Animal population Six healthy adult red-tailed hawks (Buteo jamaicensis) of unknown sex with body weights (mean +/- SD) of 1.21 +/- 0.15 kg.Methods This study was undertaken in two phases. In the first phase anaesthesia was induced with isoflurane in oxygen via facemask and maintained with isoflurane delivered in oxygen via a Bain circuit. Following instrumentation baseline determination of the MAC for isoflurane was made for each animal using the bracketing method and a supra-maximal electrical stimulus. End-tidal isoflurane concentration (E'Iso) was then set at 0.75 x MAC and after an appropriate equilibration period a bolus of fentanyl (20 mu g kg(-1)) was administered intravenously (IV) in order to determine the pharmacokinetics of fentanyl in the isoflurane-anaesthetized red-tailed hawk. During the second phase anaesthesia was induced in a similar manner and E'Iso was set at 0.75 x MAC for each individual. Fentanyl was infused IV to achieve target plasma concentrations between 8 and 32 ng mL(-1). At each fentanyl plasma concentration. the MAC for isoflurane and cardiovascular variables were determined. Data were analyzed by use of repeated-measures ANOVA.Results Mean +/- SD fentanyl plasma concentrations and isoflurane MACs were 0 +/- 0. 8.51 +/- 4. 14.85 +/- 4.82 and 29.25 +/- 11.52 ng mL(-1), and 2.05 +/- 0.45%, 1.42 +/- 0.53%. 1.14 +/- 0.31% and 0.93 +/- 0.32% for the target concentrations of 0, 8. 16 and 32 ng mL(-1), respectively. At these concentrations fentanyl significantly (p = 0.0016) decreased isoflurane MAC by 31%, 44% and 55%, respectively. Dose had no significant effect on heart rate, systolic, diastolic or mean arterial blood pressure.Conclusions and clinical relevance Fentanyl produced a dose-related decrease of isoflurane MAC with minimal effects on measured cardiovascular parameters in red-tailed hawks.