Increased macrophage colony-stimulating factor levels in patients with Graves’ disease
Increased macrophage colony-stimulating factor levels in patients with Graves’ disease
复制标题
格雷夫斯病患者巨噬细胞集落刺激因子水平升高
DOI：
10.1007/s12185-008-0155-7
复制
发表时间：
2008
影响因子：
2.1
通讯作者：
S. Ohtake
中科院分区：
文献类型：
--
作者：
E. Morishita;Akiko Sekiya;Tomoe Hayashi;Y. Kadohira;M. Maekawa;M. Yamazaki;H. Asakura;S. Nakao;S. Ohtake
先前的研究发现Graves病（GD）患者血清中促炎细胞因子浓度显著升高。我们研究了巨噬细胞集落刺激因子（M-CSF）在GD中的作用。我们测定了32例GD患者（25例未经治疗，7例接受甲巯咪唑治疗）血清中M-CSF的浓度。我们还研究了32名年龄匹配的健康受试者作为对照。研究血清M-CSF与甲状腺状态及血脂的关系。此外，为了检查甲状腺激素单独对血清M-CSF的影响，对正常受试者口服T3。GD甲亢患者血清M-CSF浓度显著高于正常组（P < 0.05）和对照组（P < 0.0001）。患者血清M-CSF浓度与T3水平呈显著正相关（r = 0.51，P < 0.005）。5例患者血清M-CSF浓度明显降低（P < 0.05），在甲状腺功能正常时达到正常对照值。15名志愿者口服T3 7天后，血清M-CSF水平显著升高（P < 0.05）。血清M-CSF和血清甲状腺激素水平之间的密切相关性表明，高循环水平的甲状腺激素可能直接或间接增强GD患者M-CSF的产生。
Previous studies have found markedly elevated serum concentrations of proinflammatory cytokines in patients with Graves’ disease (GD). We investigated the role of macrophage colony-stimulating factor (M-CSF) in GD. We assayed concentrations of M-CSF in sera from 32 patients with GD (25 untreated; 7 receiving thiamazole therapy). We also studied 32 age-matched healthy subjects as controls. Relationships between serum M-CSF and both thyroid state and serum lipids were examined. Moreover, to examine the effect of thyroid hormone alone on serum M-CSF, T3 was administered orally to normal subjects. Serum concentrations of M-CSF in GD patients who were hyperthyroid were significantly increased compared with GD patients who were euthyroid (P < 0.05) and control subjects (P < 0.0001). Serum M-CSF concentrations correlated closely with T3 levels in patients (r = 0.51, P < 0.005). Serial measurement of five individual patients revealed that serum concentrations of M-CSF were significantly decreased (P < 0.05), reaching normal control values upon attainment of euthyroidism. Furthermore, oral T3 administered to 15 volunteers for 7 days produced significant increases in serum levels of M-CSF (P < 0.05). The close correlation between serum M-CSF and serum thyroid hormone levels suggests that high circulating levels of thyroid hormones may directly or indirectly potentiate the production of M-CSF in patients with GD.
大鼠中载脂蛋白 B mRNA 编辑受甲状腺激素类似物调节，但不受生长激素的调节。
DOI：
10.1210/mend-4-5-779
发表时间：
1990
期刊：
Molecular endocrinology (Baltimore, Md.)
影响因子：
--
作者：
Davidson,NO;Carlos,RC;Lukaszewicz,AM
通讯作者：
Lukaszewicz,AM