Core-shell Fe3O4@NaLuF4:Yb,Er/Tm nanostructure for MRI, CT and upconversion luminescence tri-modality imaging.
Core-shell Fe3O4@NaLuF4:Yb,Er/Tm nanostructure for MRI, CT and upconversion luminescence tri-modality imaging.
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DOI：
10.1016/j.biomaterials.2012.03.007
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发表时间：
2012-06
期刊：
影响因子：
14
通讯作者：
Xingjun Zhu;Jing Zhou;Min Chen;Mei Shi;Wei Feng;Fuyou Li
中科院分区：
文献类型：
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作者：
Xingjun Zhu;Jing Zhou;Min Chen;Mei Shi;Wei Feng;Fuyou Li
采用逐步合成方法开发了具有多功能特性的核壳 Fe3O4@NaLuF4:Yb,Er/Tm 纳米结构（MUCNP）。透射电子显微镜、粉末X射线衍射、能量色散X射线分析和X射线光电子能谱证实了MUCNP的成功制备。 MUCNP 表现出超顺磁性，饱和磁化强度为 15 emu g−1，T2 增强磁共振 (MR) 效应在 0.5 T 时 r2 值为 21.63 s−1mM−1，由 Fe3O4 核心产生。此外，基于 NaLuF4 的 MUCNP 在 980 nm 激发下提供出色的 X 射线衰减和上转换发光 (UCL) 发射。荷瘤小鼠的体内 MR、计算机断层扫描 (CT) 和 UCL 图像表明，MUCNP 可成功用于多模态成像。体外测试表明 MUCNP 无细胞毒性。这些结果表明，所开发的 MUCNP 可用作三模态成像的 MR、CT 和 UCL 探针。
Core–shell Fe3O4@NaLuF4:Yb,Er/Tm nanostructure (MUCNP) with multifunctional properties has been developed using a step-wise synthetic method. The successful fabrication of MUCNP has been confirmed by transmission electron microscopy, powder X-ray diffraction, energy-dispersive X-ray analysis and X-ray photoelectron spectroscopy. The MUCNP exhibits superparamagnetic property with saturation magnetization of 15 emu g−1, and T2-enhanced magnetic resonance (MR) effect with an r2value of 21.63 s−1mM−1at 0.5 T, resulting from the Fe3O4cores. Moreover, the NaLuF4-based MUCNP provides excellent X-ray attenuation and upconversion luminescence (UCL) emission under excitation at 980 nm. In vivo MR, computed tomography (CT) and UCL images of tumor-bearing mice show that the MUCNP can be successfully used in multimodal imaging. In vitro tests reveal that the MUCNP is non-cytotoxic. These results suggest that the developed MUCNP could be served as an MR, CT and UCL probe for tri-modality imaging.