Nonadipose tissue production of leptin: Leptin as a novel placenta-derived hormone in humans
Nonadipose tissue production of leptin: Leptin as a novel placenta-derived hormone in humans
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DOI：
10.1038/nm0997-1029
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发表时间：
1997-09-01
期刊：
影响因子：
82.9
通讯作者：
Nakao, K
中科院分区：
文献类型：
--
作者：
Masuzaki, H;Ogawa, Y;Nakao, K
瘦素是一种循环激素，在脂肪组织中大量特异表达（1-5）。它参与调节能量稳态，以及神经内分泌和生殖系统（6-11）。在这里，我们证明了非脂肪组织，即胎盘滋养细胞和孕妇子宫的羊膜细胞产生瘦素。我们表明，与未怀孕的肥胖妇女相比，孕妇从胎盘分泌相当数量的瘦素进入母体循环。在培养的人绒毛膜癌细胞系BeWo细胞中也检测到瘦素的产生，并在福斯克林诱导的细胞滋养层细胞向合细胞滋养层细胞分化过程中增加。血浆瘦素水平在葡萄胎或绒毛膜癌患者中显著升高，在手术或化疗后降低。原代培养的人羊膜细胞也能产生瘦素，并分泌到羊水中。本研究为瘦素作为一种新的人类胎盘源性激素提供了证据，并提示瘦素在正常妊娠和妊娠滋养细胞肿瘤中的生理和病理生理意义。
Leptin is a circulating hormone that is expressed abundantly and specifically in the adipose tissue(1-5). It is involved in the regulation of energy homeostasis, as well as the neuroendocrine and reproductive systems(6-11). Here, we demonstrate production of leptin by nonadipose tissue, namely, placental trophoblasts and amnion cells from uteri of pregnant women. We show that pregnant women secrete a considerable amount of leptin from the placenta into the maternal circulation as compared with nonpregnant obese women. Leptin production was also detected in a cultured human choriocarcinoma cell line, BeWo cells, and was augmented during the course of forskolin-induced differentiation of cytotrophoblasts into syncytiotrophoblasts. Plasma leptin levels were markedly elevated in patients with hydatidiform mole or choriocarcinoma and were reduced after surgical treatment or chemotherapy. Leptin is also produced by primary cultured human amnion cells and is secreted into the amniotic fluid. The present study provides evidence for leptin as a novel placenta-derived hormone in humans and suggests the physiologic and pathophysiologic significance of leptin in normal pregnancy and gestational trophoblastic neoplasms.