Exhaled nitric oxide and nasal tryptase are associated with wheeze, rhinitis and nasal allergy in primary school children
Exhaled nitric oxide and nasal tryptase are associated with wheeze, rhinitis and nasal allergy in primary school children
复制标题
呼出的一氧化氮和鼻类胰蛋白酶与小学生喘息、鼻炎和鼻过敏有关
作者：
Sofie De Prins;F. Marcucci;L. Sensi;E. Van de Mieroop;V. Nelen;T. Nawrot;G. Schoeters;G. Koppen
摘要鼻炎和哮喘是儿童最常见的呼吸系统疾病。我们从流行病学的角度评估了130名6-12岁儿童的呼吸道炎症标志物是否与鼻部过敏以及自我报告的喘息和鼻炎症状有关。呼气一氧化氮(FeNO)和鼻肥大细胞(MC)激活(类胰酶≥ 5 ng/m L)与喘鸣、鼻炎和鼻变态反应呈正相关，与性别和年龄无关。鼻腔嗜酸性粒细胞阳离子蛋白和呼气冷凝液标志物(pH、8-异前列腺素、白细胞介素1β)与症状或鼻腔过敏无关。总而言之，FeNO和鼻腔类胰蛋白酶反映了呼吸系统的过敏性炎症。
Abstract Rhinitis and asthma are the most common respiratory diseases in children. We assessed whether airway inflammation markers were associated with nasal allergies and self-reported symptoms of wheeze and rhinitis in 130 children 6–12 year old in an epidemiological context. Independent of sex and age, the fraction of exhaled nitric oxide (FeNO) and nasal mast cell (MC) activation (tryptase ≥ 5 ng/mL) were positively associated with wheeze, rhinitis and with nasal allergy. Nasal eosinophil cationic protein (ECP) and exhaled breath condensate (EBC) markers (pH, 8-isoprostane, interleukin-1β) were not associated with symptoms or with nasal allergy. In conclusion, FeNO and nasal tryptase reflect allergic inflammation in the respiratory system.
呼出气冷凝液 pH 值测定。
影响因子：
2.6
作者：
Davis,MichaelD;Hunt,John
通讯作者：
Hunt,John