Histologic Observations in Human Hepatitis Non‐A, Non‐B
Histologic Observations in Human Hepatitis Non‐A, Non‐B
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人类非甲型、非乙型肝炎的组织学观察
DOI：
10.1002/hep.1840020509
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发表时间：
2007
期刊：
影响因子：
13.5
通讯作者：
H. Lobeck
中科院分区：
文献类型：
--
作者：
H. Dienes;H. Popper;W. Arnold;H. Lobeck
对57例急性或慢性非甲非乙肝炎（HNANB）患者的标本进行了光镜研究，其中22例为电子显微镜。将它们与存档的甲型肝炎和乙型肝炎标本或与HNANB病例同时获得的标本进行比较。在HNANB材料中，在小叶实质中单独或合并发现两种光镜下病变。一种是肝细胞细胞质的嗜酸性改变，与许多嗜酸体相关。明显的改变常伴有微泡性脂肪变性。该病变与电子显微镜检测到的核颗粒有关。第二种病变包括在某些病例中突出的窦状细胞激活。从黑猩猩的经验来看，这些特征被暂时认为是同一过程的阶段。这两种病变都与门静脉和通常轻度门静脉周围炎症有关，而门静脉周围炎症与实质反应的程度和类型无关。他们也观察到在慢性阶段，使区分急性和慢性HNANB困难。活动性乙型肝炎似乎与HNANB不同，主要是小叶实质中明显存在淋巴细胞，经常与肝细胞、嗜酸体接触，并且有更均匀的门静脉炎症反应。在甲型肝炎中，肝细胞损伤明显发生在门静脉周围。在HNANB中，细胞病变效应而不是淋巴细胞免疫攻击似乎比其他形式的病毒性肝炎更重要。小叶主要嗜酸性粒细胞改变的复发可能是慢性的原因。
Specimens from 57 patients with acute or chronic hepatitis non‐A, non‐B (HNANB), mostly mild to moderate, were studied by light and, in 22 instances, by electron microscopy. They were compared to specimens of hepatitis A and hepatitis B on file or obtained simultaneously with the HNANB cases. In the HNANB material, two types of light‐microscopic lesions were noted in the lobular parenchyma singly or in combination. One was an eosinophilic alteration of the hepatocytic cytoplasm associated with many acidophilic bodies. Conspicuous alteration were often accompanied by microvesicular steatosis. This lesion was associated with nuclear particles detectable by electron microscopy. The second lesion consisted of sinusoidal cell activation which was prominent in some cases. From experiences with chimpanzees, these features were tentatively considered to be stages of the same process. Both lesions were associated with portal and usually mild periportal inflammation which was not related to the degree and type of parenchymal reaction. They were also observed in chronic stages, making the differentiation between acute and chronic HNANB difficult. Active hepatitis B seems to differ from HNANB primarily by the conspicuous presence of lymphocytes in the lobular parenchyma often in contact with hepatocytes, acidophilic bodies, and a more uniform portal inflammatory reaction. In hepatitis A, hepatocellular injury was conspicuously periportal. In HNANB, a cytopathic effect rather than lymphocytic immune attack appears to be of greater significance than in the other forms of viral hepatitis. The recurrence of lobular mainly eosinophilic changes may explain chronicity.
非甲非乙型肝炎患者肝细胞的核变化。
影响因子：
29.4
作者：
Cabral,GA;Marciano-Cabral,F;Patterson,M;Galen,EA;Carithers,RL
通讯作者：
Carithers,RL
非甲、非乙型输血后肝炎的长期病程。
影响因子：
29.4
作者：
Koretz,RL;Stone,O;Gitnick,GL
通讯作者：
Gitnick,GL