Low maternal vitamin D status in pregnancy increases the risk of childhood obesity
Low maternal vitamin D status in pregnancy increases the risk of childhood obesity
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DOI：
10.1111/ijpo.12267
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发表时间：
2018-08-01
影响因子：
3.8
通讯作者：
Chatzi, L.
中科院分区：
文献类型：
--
作者：
Daraki, V.;Roumeliotaki, T.;Chatzi, L.
背景：维生素D可能调节脂肪形成。然而，有限的研究调查了怀孕期间母亲维生素D对后代肥胖或心脏代谢参数的影响，结果不确定。目的：本研究的目的是检查来自希腊克里特岛的532对准怀孕队列Rhea的母亲25(OH)-维生素D [25(OH)D]状态与后代肥胖和心脏代谢特征的关系。方法：在第一次产前检查（平均14周，标准差4）时测定产妇25(OH)D浓度。儿童结局包括4岁和6岁时的体重指数标准差评分、腰围、皮肤褶皱厚度、血压和血脂。6岁时也测量了体脂率。体重指数从出生到6岁的增长轨迹由年龄分数多项式的混合效应模型估计。通过多变量线性回归分析获得调整后的相关性。结果：大约三分之二的参与调查的母亲有25(OH)D浓度
Background: Vitamin D may modulate adipogenesis. However, limited studies have investigated the effect of maternal vitamin D during pregnancy on offspring adiposity or cardiometabolic parameters with inconclusive results.Objectives: The objective of this study is to examine the association of maternal 25(OH)-vitamin D [25(OH)D] status with offspring obesity and cardiometabolic characteristics in 532 mother-child pairs from the prospective pregnancy cohort Rhea in Crete, Greece.Methods: Maternal 25(OH)D concentrations were measured at the first prenatal visit (mean: 14 weeks, SD: 4). Child outcomes included body mass index standard deviation score, waist circumference, skin-fold thickness, blood pressure and serum lipids at ages 4 and 6 years. Body fat percentage was also measured at 6 years. Body mass index growth trajectories from birth to 6 years were estimated by mixed effects models with fractional polynomials of age. Adjusted associations were obtained via multivariable linear regression analyses.Results: About two-thirds of participating mothers had 25(OH)D concentrations