Cell-based therapies and imaging in cardiology
Cell-based therapies and imaging in cardiology
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DOI：
10.1007/s00259-005-1898-5
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发表时间：
2005-12-01
影响因子：
9.1
通讯作者：
Dimmeler, Stefanie
中科院分区：
文献类型：
--
作者：
Bengel, Frank M.;Schachinger, Volker;Dimmeler, Stefanie
心脏修复的细胞疗法已成为心血管医学中最令人兴奋和最有前途的发展之一。来自实验和临床研究的证据越来越多，这种创新的治疗方法将影响未来的临床实践。但是，关于这种疗法的基本机制的开放性问题和争议仍然存在，并强调需要特定的技术来可视化体内治疗的机制和成功。已经介绍了几种旨在跟踪心脏中移植细胞的非侵入性成像方法。其中包括用放射性核素或顺磁试剂直接标记细胞，以及使用报告基因对细胞移植和分化进行成像。初步研究表明，这些分子成像技术具有很大的潜力。将细胞成像整合到心脏细胞治疗的研究中有望促进该领域的进一步发展，使其成为广泛的临床有用的应用。
Cell therapy for cardiac repair has emerged as one of the most exciting and promising developments in cardiovascular medicine. Evidence from experimental and clinical studies is increasing that this innovative treatment will influence clinical practice in the future. But open questions and controversies with regard to the basic mechanisms of this therapy continue to exist and emphasise the need for specific techniques to visualise the mechanisms and success of therapy in vivo. Several non-invasive imaging approaches which aim at tracking of transplanted cells in the heart have been introduced. Among these are direct labelling of cells with radionuclides or paramagnetic agents, and the use of reporter genes for imaging of cell transplantation and differentiation. Initial studies have suggested that these molecular imaging techniques have great potential. Integration of cell imaging into studies of cardiac cell therapy holds promise to facilitate further growth of the field towards a broadly clinically useful application.