Resting-state functional connectivity in major depression: Abnormally increased contributions from subgenual cingulate cortex and thalamus
Resting-state functional connectivity in major depression: Abnormally increased contributions from subgenual cingulate cortex and thalamus
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DOI：
10.1016/j.biopsych.2006.09.020
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发表时间：
2007-09-01
影响因子：
10.6
通讯作者：
Schatzberg, Alan F.
中科院分区：
文献类型：
--
作者：
Greicius, Michael D.;Flores, Benjamin H.;Schatzberg, Alan F.
背景资料：正电子发射断层扫描（PET）的研究显示，抑郁症的休息状态异常的前额叶和扣带皮层。最近，功能磁共振成像已被调整，以检查一个特定的休息状态的神经网络默认模式网络，其中包括内侧前额叶和前扣带皮层的连接。本研究的目的是检查静息状态，默认模式的网络功能连接在受试者与抑郁症和健康controls.Methods：28例受试者与抑郁症和20名健康对照进行了5分钟的fMRI扫描，而安静地休息。独立成分分析被用来隔离在每个主题的默认模式网络。组映射的默认模式网络进行了比较。在抑郁组进行组内分析，探讨抑郁难治性对功能connections.Results的影响：静息状态下扣带回和丘脑功能连接的默认模式网络显着更大的抑郁症患者。在抑郁症组内，当前抑郁发作的时间长度与膝下扣带回的功能连接呈正相关。结论：这是第一项探讨抑郁症默认模式功能连接的研究。这些发现提供了PET研究的跨模态确认，证实了重度抑郁症患者丘脑和膝下扣带回活动增加。此外，这里采用的受试者内连接分析将这些先前孤立的高代谢区域带入了无序神经网络的背景下。不应症和膝下扣带回功能连接网络内的相关性表明，定量，静息状态的功能磁共振成像测量可用于指导治疗个别科目。
Background: Positron emission tomography (PET) studies of major depression have revealed resting-state abnormalities in the prefrontal and cingulate cortices. Recently, fMRI has been adapted to examine connectivity within a specific resting-state neural network-the default-mode network-that includes medial prefrontal and anterior cingulate cortices. The goal of this study was to examine resting-state, default-mode network functional connectivity in subjects with major depression and in healthy controls.Methods: Twenty-eight subjects with major depression and 20 healthy controls underwent 5-min fMRl scans while resting quietly. Independent component analysis was used to isolate the default-mode network in each subject. Group maps of the default-mode network were compared. A within-group analysis was performed in the depressed group to explore effects of depression refractoriness on functional connectivity.Results: Resting-state subgenual cingulate and thalamic functional connectivity with the default-mode network were significantly greater in the depressed subjects. Within the depressed group, the length of the current depressive episode correlated positively with functional connectivity in the subgenual cingulate.Conclusions: This is the first study to explore default-mode functional connectivity in major depression. The findings provide crossmodality confirmation of PET studies demonstrating increased thalamic and subgenual cingulate activity in major depression. Further, the within-subject connectivity analysis employed here brings these previously isolated regions of hypermetabolism into the context of a disordered neural network. The correlation between refractoriness and subgenual cingulate functional connectivity within the network suggests that a quantitative, resting-state fMRI measure could be used to guide therapy in individual subjects.