Environmental tobacco smoke and risk of malignant lymphoma in pet cats
Environmental tobacco smoke and risk of malignant lymphoma in pet cats
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DOI：
10.1093/aje/kwf044
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发表时间：
2002-08-01
影响因子：
5
通讯作者：
Moore, AS
中科院分区：
文献类型：
--
作者：
Bertone, ER;Snyder, LA;Moore, AS
猫恶性淋巴瘤常见于家猫，可作为人类非霍奇金淋巴瘤的模型。一些研究表明，吸烟可能会增加非霍奇金淋巴瘤的风险。为了评估暴露于家庭环境烟草烟雾（ETS）是否可能增加猫恶性淋巴瘤的风险，作者对1993年至2000年期间在马萨诸塞州一家大型兽医教学医院诊断的80只恶性淋巴瘤猫和114只肾病对照猫进行了一项病例对照研究。所有受试者的主人都收到了一份调查问卷，询问诊断前2年家庭的吸烟水平。校正年龄和其他因素后，任何家庭ETS暴露的猫患恶性淋巴瘤的相对风险为2.4（95%置信区间：1.2，4.5）。风险随着接触时间和数量的增加而增加，有证据表明呈线性趋势。与非吸烟家庭相比，ETS暴露5年或更长时间的猫的相对风险为3.2（95%置信区间：1.5，6.9;趋势p = 0.003）。这些研究结果表明，被动吸烟可能会增加猫患恶性淋巴瘤的风险，并在人类中进一步研究这种关系是必要的。
Feline malignant lymphoma occurs commonly in domestic cats and may serve as a model for non-Hodgkin's lymphoma in humans. Several studies have suggested that smoking may increase the risk of non-Hodgkin's lymphoma. To evaluate whether exposure to household environmental tobacco smoke (ETS) may increase the risk of feline malignant lymphoma, the authors conducted a case-control study of this relation in 80 cats with malignant lymphoma and 114 controls with renal disease diagnosed at a large Massachusetts veterinary teaching hospital between 1993 and 2000. Owners of all subjects were sent a questionnaire inquiring about the level of smoking in the household 2 years prior to diagnosis. After adjustment for age and other factors, the relative risk of malignant lymphoma for cats with any household ETS exposure was 2.4 (95 percent confidence interval: 1.2, 4.5). Risk increased with both duration and quantity of exposure, with evidence of a linear trend. Cats with 5 or more years of ETS exposure had a relative risk of 3.2 (95 percent confidence interval: 1.5, 6.9; p for trend = 0.003) compared with those in nonsmoking households. These findings suggest that passive smoking may increase the risk of malignant lymphoma in cats and that further study of this relation in humans is warranted.