Natural small molecules as inhibitors of coronavirus lipid-dependent attachment to host cells: a possible strategy for reducing SARS-COV-2 infectivity?
Natural small molecules as inhibitors of coronavirus lipid-dependent attachment to host cells: a possible strategy for reducing SARS-COV-2 infectivity?
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DOI：
10.23750/abm.v91i1.9402
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发表时间：
2020-03-19
期刊：
影响因子：
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通讯作者：
Bertelli M
中科院分区：
文献类型：
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作者：
Baglivo M;Baronio M;Natalini G;Beccari T;Chiurazzi P;Fulcheri E;Petralia PP;Michelini S;Fiorentini G;Miggiano GA;Morresi A;Tonini G;Bertelli M
病毒感染性取决于宿主细胞质膜和病毒包膜成分之间的相互作用。在这里，我们回顾了可能有助于阻止SARS-COV-2流行病发展的策略。我们专注于脂质结构的作用，如脂筏和胆固醇，参与的过程中，介导的内吞作用，病毒附着和感染细胞。先前的研究表明，许多天然来源的物质，如环糊精和甾醇，可以通过干扰脂质依赖性附着到人类宿主细胞来降低许多类型病毒的感染性，包括冠状病毒家族。某些分子被证明能够降低某些冠状病毒的感染性，可能是通过抑制病毒对宿主细胞的脂质依赖性附着。对这些分子和方法的更多研究将是值得的，因为它可以提供SARS-COV-2传播机制的见解，以及它们如何成为新的抗病毒策略的基础。
Viral infectivity depends on interactions between components of the host cell plasma membrane and the virus envelope. Here we review strategies that could help stem the advance of the SARS-COV-2 epidemic. We focus on the role of lipid structures, such as lipid rafts and cholesterol, involved in the process, mediated by endocytosis, by which viruses attach to and infect cells. Previous studies have shown that many naturally derived substances, such as cyclodextrin and sterols, could reduce the infectivity of many types of viruses, including the coronavirus family, through interference with lipid-dependent attachment to human host cells. Certain molecules prove able to reduce the infectivity of some coronaviruses, possibly by inhibiting viral lipid-dependent attachment to host cells. More research into these molecules and methods would be worthwhile as it could provide insights the mechanism of transmission of SARS-COV-2 and, into how they could become a basis for new antiviral strategies.