Chinese medicinal herbs in relieving perimenopausal depression: a randomized, controlled trial.
Chinese medicinal herbs in relieving perimenopausal depression: a randomized, controlled trial.
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DOI：
10.1089/acm.2008.0267
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发表时间：
2009-01
影响因子：
2.6
通讯作者：
F. Qu;Xuefen Cai;Ying-Er Gu;Jue Zhou;Runju Zhang;Elizabeth Burrows;He-Feng Huang
中科院分区：
文献类型：
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作者：
F. Qu;Xuefen Cai;Ying-Er Gu;Jue Zhou;Runju Zhang;Elizabeth Burrows;He-Feng Huang
目的探讨中药复方更年乐（又称围绝经期抑郁方）治疗围绝经期抑郁症的临床疗效。方法2004 - 09/2008 - 04，采用随机表法将47例中国女性患者随机分为GNL组（n = 21）和替勃龙对照组（n = 26）。采用24项汉密尔顿抑郁量表（HAMD）评定抑郁程度。治疗前后检测血清促卵泡激素（FSH）、促黄体生成素（LH）、雌二醇（E2）水平。结果治疗12周后，两组HAMD评分均较治疗前明显下降（p0.05）.两组FSH水平均显著降低，E2水平均显著升高，且对照组变化更大。治疗期间，两组均未报告治疗副作用。结论中药复方更年灵具有较好的缓解围绝经期抑郁的作用，值得进一步研究。
OBJECTIVE To explore the effects of GengNianLe (GNL, also called perimenopausal depression relieving formula), a defined formula of Chinese medicinal herbs in relieving perimenopausal depression in Chinese women. METHODS Between September 2004 and April 2008, 47 Chinese women were randomized into a GNL group (n = 21) and a control group which received tibolone (n = 26) using a randomization chart. Depression was rated with the 24-item Hamilton Depression Scale (HAMD). The serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), and estradiol (E(2)) were detected before and after the treatment. RESULTS After 12 weeks of treatment, HAMD scores in both groups decreased significantly (p 0.05). The levels of FSH decreased significantly and the level of E(2) increased significantly in both groups, and they changed more in the control group. No side-effect of treatment was reported in either group during treatment. CONCLUSIONS The Chinese medicinal formula GNL showed promise in relieving perimenopausal depression and merits further study.