Unbalanced expression of VEGF and PEDF in ischemia-induced retinal neovascularization
Unbalanced expression of VEGF and PEDF in ischemia-induced retinal neovascularization
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DOI：
10.1016/s0014-5793(01)02110-x
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发表时间：
2001-02-02
期刊：
影响因子：
3.5
通讯作者：
Ma, JX
中科院分区：
文献类型：
--
作者：
Gao, GQ;Li, Y;Ma, JX
本研究测定了大鼠视网膜血管内皮生长因子（VEGF）和色素上皮衍生因子（PEDF）的水平，并与缺血诱导的视网膜新生血管形成进行了相关性研究。与年龄匹配的对照组相比，新生血管形成的视网膜中VEGF增加5倍，而PEDF减少2倍，导致VEGF/PEDF比值增加。VEGF/PEDF比值变化的时间进程与视网膜新生血管的进展相关。VEGF和PEDF mRNA的变化先于其蛋白水平的变化。这些结果表明，血管生成刺激剂和抑制剂之间的不平衡可能有助于视网膜新生血管形成。(C)2001年欧洲生物化学学会联合会。由Elsevier Science B. V.出版，版权所有。
Retinal levels of vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF), an angiogenic inhibitor, mere measured and correlated with the ischemia-induced retinal neovascularization in rats, The retinas with neovascularization showed a 5-fold increase in VEGF while 2-fold decrease in PEDF, compared to the age-matched controls, resulting in an increased VEGF/PEDF ratio. The time course of the VEGF/PEDF ratio change correlated with the progression of retinal neovascularization. Changes in the VEGF and PEDF mRNAs preceded their protein level changes. These results suggest that an unbalance between angiogenic stimulators and inhibitors may contribute to retinal neovascularization. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.