Precision Polymers - Modern Tools to Understand and Program Macromolecular Interactions
Precision Polymers - Modern Tools to Understand and Program Macromolecular Interactions
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DOI：
10.1002/marc.201000646
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发表时间：
2011-01-17
影响因子：
4.6
通讯作者：
Boerner, Hans G.
中科院分区：
文献类型：
--
作者：
Boerner, Hans G.
由普通合成聚合物部分和单分散、单体序列限定的链段组成的AB嵌段共聚物被认为属于“精密聚合物”类别。“这篇综述总结了那些可精确调节的功能聚合物在材料科学应用中的可能性。离散肽段的可自由编程的单体序列允许调节性质，例如相互作用能力。这可以用于（i）特异性溶解和运输低分子量药物，（ii）包装DNA，（iii）指导结晶，或（iv）调节细胞在材料表面上的粘附行为。从蛋白质中可以看出，提高合成大分子精度的空间将提供大量机会。
AB-block copolymers composed of a common synthetic polymer part and a monodisperse, monomer sequence-defined segment are considered belonging to the class of "Precision Polymers." This overview summarizes the possibilities that arise from those precisely adjustable, functional polymers for materials science applications. The freely programmable monomer sequence of the discrete peptide segment allows adjusting properties such as interaction capabilities. This can be exploited to (i) specifically solubilize and transport low molecular weight drugs, (ii) to pack DNA, (iii) to direct crystallization, or (iv) to modulate adhesion behavior of cells on material surfaces. As evident from proteins, the room to improve the precision of synthetic macromolecules will offer plenty of opportunities.