CD8+ T lymphocytes and leukotriene B4:: Novel interactions in the persistence and progression of asthma
CD8+ T lymphocytes and leukotriene B4:: Novel interactions in the persistence and progression of asthma
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DOI：
10.1016/j.jaci.2005.12.1340
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发表时间：
2006-03-01
影响因子：
14.2
通讯作者：
Dakhanna, A
中科院分区：
文献类型：
--
作者：
Gelfand, EW;Dakhanna, A
近年来，CD 8（+）T细胞在气道高反应性和气道炎症发生发展中的作用受到越来越多的关注。CD 8（+）T细胞能够分泌T（H）2细胞因子，包括IL-4、IL-5和IL-13，已在哮喘受试者和过敏原致敏和激发的动物中描述。这些产生IL-13的CD 8（+）T细胞的一个亚群，即小鼠中的效应记忆CD 8（+）T细胞，表达对白三烯B-4（BLT 1）的高亲和力受体，并且该受体的表达对于它们在肺中的积累以及气道高反应性和气道炎症的发展是必需的。在哮喘受试者的支气管肺泡灌洗液中也发现了类似的CD 8（+）/BLT 1（+）/IL-13（+）T细胞亚群，表明这种独特的CD 8（+）T细胞亚群在哮喘中具有致病作用。
The contribution of CD8(+) T cells to the development of airway hyperresponsiveness and airway inflammation has received increased attention recently. CD8(+) T cells, which are capable of secreting T(H)2 cytokines, including IL-4, IL-5, and IL-13, have been described in asthmatic subjects and in animals sensitized and challenged with allergen. A subset of these IL-13-producing CD8(+) T cells, effector memory CD8(+) T cells in the mouse, express a high-affinity receptor for leukotriene B-4 (BLT1), and expression of this receptor is essential for their accumulation in the lung and development of airway hyperresponsiveness and airway inflammation. A similar subset of CD8(+)/BLT1(+)/IL-13(+) T cells has also been identified in the bronchoalveolar lavage fluid of asthmatic subjects, suggesting a pathogenic role for this unique subset of CD8(+) T cells in asthma.