Free-Breathing Liver Fat, R₂* and B₀ Field Mapping Using Multi-Echo Radial FLASH and Regularized Model-Based Reconstruction.
Free-Breathing Liver Fat, R₂* and B₀ Field Mapping Using Multi-Echo Radial FLASH and Regularized Model-Based Reconstruction.
复制标题
使用多回波径向闪光和基于正则化模型的重建进行自由呼吸肝脏脂肪、R* 和 B 场映射。
DOI：
10.1109/tmi.2022.3228075
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发表时间：
2023
影响因子：
10.6
通讯作者：
Uecker,Martin
中科院分区：
文献类型：
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作者：
Tan,Zhengguo;Unterberg-Buchwald,Christina;Blumenthal,Moritz;Scholand,Nick;Schaten,Philip;Holme,Christian;Wang,Xiaoqing;Raddatz,Dirk;Uecker,Martin
这项工作介绍了一种用于自由呼吸肝脏体积采集的放射状多回声不对称回声MRI序列。在Berkeley高级重建工具箱(BART)中实现了基于正则化模型的重建，以联合估计来自自选通空间数据的所有物理参数图(水、脂肪、Andfield非均匀性图)和线圈敏感性图。具体地说，直接在物理参数图上采用局部低阶正则和时间全变差正则化。所提出的自由呼吸放射状技术在一个水/脂肪和铁的模体、一名年轻的志愿者和肥胖/糖尿病/肝脏脂肪变性患者身上进行了测试。通过将我们的技术与参考屏气笛卡尔扫描进行比较，证实了定量脂肪分数和准确性。多回波径向采样序列实现了快速的空间覆盖，并且对运动具有健壮性。此外，提出的基于运动分辨模型的重建允许自由呼吸的肝脏脂肪和在多个运动状态下的量化。总体而言，我们建议的技术为无屏气要求的非侵入性肝脏评估提供了一种方便的工具。
This work introduced a stack-of-radial multi-echo asymmetric-echo MRI sequence for free-breathing liver volumetric acquisition. Regularized model-based reconstruction was implemented in Berkeley Advanced Reconstruction Toolbox (BART) to jointly estimate all physical parameter maps (water, fat,, andfield inhomogeneity maps) and coil sensitivity maps from self-gated-space data. Specifically, locally low rank and temporal total variation regularization were employed directly on physical parameter maps. The proposed free-breathing radial technique was tested on a water/fat & iron phantom, a young volunteer, and obesity/diabetes/hepatic steatosis patients. Quantitative fat fraction andaccuracy were confirmed by comparing our technique with the reference breath-hold Cartesian scan. The multi-echo radial sampling sequence achieves fast-space coverage and is robust to motion. Moreover, the proposed motion-resolved model-based reconstruction allows for free-breathing liver fat andquantification in multiple motion states. Overall, our proposed technique offers a convenient tool for non-invasive liver assessment with no breath holding requirement.