Antibacterial efficacy from NO-releasing MOF-polymer films
Antibacterial efficacy from NO-releasing MOF-polymer films
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DOI：
10.1039/d0ma00650e
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发表时间：
2020-10-01
影响因子：
5
通讯作者：
Morris, Russell E.
中科院分区：
文献类型：
--
作者：
Duncan, Morven J.;Wheatley, Paul S.;Morris, Russell E.
本文首次报道了一种释放一氧化氮（NO）的mof -聚氨酯薄膜的配方及其抗菌效果。成功制备了含有1、5、10和15 wt% CPO-27 （Ni）的均匀独立薄膜。每个膜内的MOF都被成功激活并加载了NO。本文报道了膜的吸附和释放曲线，并表明聚合物影响MOF吸附和储存NO的数量以及释放的时间尺度；所储存的一氧化氮被释放的比例取决于薄膜中MOF的装载量的wt%。在细胞毒性试验中，该配方显示出非常低的毒性(
The formulation and antibacterial efficacy of nitric oxide (NO)-releasing MOF-polyurethane films are reported for the first time. Uniform standalone films were successfully prepared containing 1, 5, 10, and 15 wt% CPO-27 (Ni). The MOF within each film was successfully activated and loaded with NO. Adsorption and release profiles are reported for the films and show that while the polymer influences the quantity of NO adsorbed and stored by the MOF and the time scale of release; the proportion of stored NO that is released is dependent on wt% loading of MOF in the film. In a cytotoxicity assay, the formulations exhibited very low toxicity (