Recombinant epidermolytic (exfoliative) toxin A of Staphylococcus aureus is not a superantigen
Recombinant epidermolytic (exfoliative) toxin A of Staphylococcus aureus is not a superantigen
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金黄色葡萄球菌重组表皮松解（剥脱）毒素 A 不是超抗原
DOI：
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发表时间：
2004
期刊：
影响因子：
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通讯作者：
C. Bailey
中科院分区：
文献类型：
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作者：
B. Fleischer;C. Bailey
金黄色葡萄球菌产生的表皮松解（剥脱）毒素引起表皮松解和皮肤起泡。此外，它们被认为属于T淋巴细胞刺激分子组，称为“超级抗原”。本研究表明，金黄色葡萄球菌产生的重组表皮松解毒素A对人和小鼠T淋巴细胞不具有丝分裂性。我们讨论了高度有丝分裂外蛋白的微小污染可能导致几种被报道为超级抗原的蛋白质的有丝分裂性。
The epidermolytic (exfoliative) toxins produced by Staphylococcus aureus cause epidermolysis and skin blistering. In addition, they have been implicated to belong to the group of T lymphocyte stimulating molecules known as “superantigens”. Here we show that recombinant epidermolytic toxin A produced in S. aureus is not mitogenic for human and murine T lymphocytes. We discuss the possibility that minute contaminations of highly mitogenic exoproteins may cause the mitogenicity in several proteins that are reported to be superantigens.