P300 from amnesic patients with bilateral hippocampal lesions.
P300 from amnesic patients with bilateral hippocampal lesions.
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DOI：
10.1093/neucas/2.4.259-ab
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发表时间：
1993-06
期刊：
影响因子：
--
通讯作者：
J. Polich;L. Squire
中科院分区：
文献类型：
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作者：
J. Polich;L. Squire
应用听觉和视觉刺激记录5例无颅骨缺损的双侧海马结构损伤的遗忘症患者的P3（00）事件相关脑电位（ERP）。4名正常对照组受试者在年龄、性别、教育程度和智商分测验得分方面与每个健忘症患者相匹配（n = 20，总对照组）。所有5名健忘症患者均表现出ERP，在两种模式下，患者和对照组之间的P3振幅或潜伏期均无可靠差异。研究结果表明，海马结构并没有显着贡献头皮记录的P3从听觉和视觉的目标刺激，一个结论也支持了额外的最近的研究结果，患者的广泛的双边内侧颞叶损伤的研究。P3成分的认知加工的意义进行了讨论。
P3(00) event-related brain potentials (ERPs) were recorded using auditory and visual stimuli from 5 amnesic patients with confirmed (n = 4) or suspected (n = 1) bilateral damage to the hippocampal formation without skull defects. Four normal control subjects were matched to each amnesic patient with respect to age, sex, education, and IQ subtest scores (n = 20 total controls). All 5 amnesic patients exhibited ERPs, and no reliable differences in P3 amplitude or latency could be detected between the patients and the control subjects in either modality. The findings indicate that the hippocampal formation does not contribute significantly to the scalp-recorded P3 from auditory and visual target stimuli, a conclusion also supported by additional recent findings from studies of patients with extensive bilateral medial temporal lobe damage studies. The significance of the P3 component for cognitive processing is discussed.