Short-term oral rapamycin prevents age-related learning impairment in mice.
Short-term oral rapamycin prevents age-related learning impairment in mice.
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DOI：
10.31491/apt.2020.09.033
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发表时间：
2020-09-29
期刊：
影响因子：
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通讯作者：
Jiang Z
中科院分区：
文献类型：
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作者：
Lei H;Wang J;Ladiges W;Jiang Z
预防或延缓与年龄有关的学习障碍的有效治疗方法一般不存在。在一项初步的临床前研究中，20个月大的小鼠被喂食含有14 ppm雷帕霉素（一种mTOR抑制剂）的饮食三个月，然后在空间导航任务中进行测试。喂食非药物对照饮食的小鼠表现出学习障碍，而喂食雷帕霉素饮食的小鼠没有学习障碍。这一观察结果为额外的临床前研究提供了支持，并表明短期雷帕霉素治疗可能是预防或延迟与年龄相关的认知障碍的可能策略。
Effective treatments to prevent or delay age-related learning impairment are not generally available. In a preliminary preclinical study, mice 20 months of age were fed a diet containing 14 ppm rapamycin, an inhibitor of mTOR, for three months and then tested in a spatial navigation task. Mice fed the nonmedicated control diet showed learning impairment while mice fed the rapamycin diet were not learning impaired. This observation provides support for additional preclinical studies and suggests that short-term rapamycin treatment could be a possible strategy for preventing or delaying age-related cognitive impairment in people.