Modulation of oncogenic transformation by the human adenovirus E1A C-terminal region.
Modulation of oncogenic transformation by the human adenovirus E1A C-terminal region.
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DOI：
10.1007/978-3-662-05599-1_5
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发表时间：
2004
影响因子：
--
通讯作者：
G. Chinnadurai
中科院分区：
文献类型：
--
作者：
G. Chinnadurai
TheE1Aoncogene of human adenoviruses cooperates with other viral and cellular oncogenes in oncogenic transformation of primary and established cells. The N-terminal half of E1A proteins that form specific protein complexes with pRb family and p300/CBP transcriptional regulators is essential for the transforming activities of E1A. Although the C-terminal half of E1A is dispensable for the transforming activities, it negatively modulates the oncogenic activities of the N-terminal region. Mutants of EIA lacking the C-terminal half or a short C-terminal region exhibit a hyper-transforming phenotype in cooperative transformation assays with the activatedrasoncogene. The E1A C-terminal region implicated in the oncogenesis-restraining activity interacts with a 48-kDa cellular phosphoprotein, CtBP, that functions as a transcriptional corepressor. It appears that the C-terminal region of E1A may suppress E1A-mediated oncogenic transformation by a dual mechanism of relieving repression cellular genes by CtBP, and also by antagonizing the oncogenic activities of the N-terminal half of E1A.
