Atypical processing in neural source analysis of speech envelope modulations in adolescents with dyslexia
Atypical processing in neural source analysis of speech envelope modulations in adolescents with dyslexia
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DOI：
10.1111/ejn.15515
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发表时间：
2021-11-14
影响因子：
3.4
通讯作者：
Wouters, Jan
中科院分区：
文献类型：
--
作者：
Barbero, Raul Granados;de Vos, Astrid;Wouters, Jan
不同的研究表明，语言和发展障碍，如阅读困难，与语言处理过程中听觉夹带和功能性半球不对称的障碍有关。这些障碍通常是由语言的语音成分中的问题引起的，该问题导致在音节和/或音素水平上表示和操纵单词的语音结构的问题。我们使用脑电记录中的听觉稳态反应(ASSR)来研究典型读者和阅读障碍读者的大脑激活和大脑不对称的theta、α、beta和低伽马范围振荡。其目的是分析在以前的电极水平研究中发现的组差异是由不同的来源激活模式引起的，还是相反地是可以在活跃的大脑来源上发现的影响。我们找不到主要活跃脑来源的脑位置的差异。然而，我们观察到提取的波形有所不同。ASSR所有信噪比的第一个DSS分量在源水平上的组平均值高于电极水平上的组平均值。这些分析包括阅读障碍青少年的阿尔法同步化程度较低，以及在theta、beta和低伽马频段存在补偿机制的可能性。主要的脑听觉来源位于听觉皮质周围的皮质区域。因此，根据我们的发现，在听觉脑电实验中观察到的差异将起源于与语音感知相关的大脑皮层来源的内在振荡机制。
Different studies have suggested that language and developmental disorders such as dyslexia are associated with a disturbance of auditory entrainment and of the functional hemispheric asymmetries during speech processing. These disorders typically result from an issue in the phonological component of language that causes problems to represent and manipulate the phonological structure of words at the syllable and/or phoneme level. We used Auditory Steady-State Responses (ASSRs) in EEG recordings to investigate the brain activation and hemisphere asymmetry of theta, alpha, beta and low-gamma range oscillations in typical readers and readers with dyslexia. The aim was to analyse whether the group differences found in previous electrode level studies were caused by a different source activation pattern or conversely was an effect that could be found on the active brain sources. We could not find differences in the brain locations of the main active brain sources. However, we observed differences in the extracted waveforms. The group average of the first DSS component of all signal-to-noise ratios of ASSR at source level was higher than the group averages at the electrode level. These analyses included a lower alpha synchronisation in adolescents with dyslexia and the possibility of compensatory mechanisms in theta, beta and low-gamma frequency bands. The main brain auditory sources were located in cortical regions around the auditory cortex. Thus, the differences observed in auditory EEG experiments would, according to our findings, have their origin in the intrinsic oscillatory mechanisms of the brain cortical sources related to speech perception.