Regulation of initiation factor eIF-2B by GSK-3 regulated phosphorylation.
Regulation of initiation factor eIF-2B by GSK-3 regulated phosphorylation.
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GSK-3 调节磷酸化对起始因子 eIF-2B 的调节。
DOI：
10.1042/bst025191s
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发表时间：
1997
影响因子：
3.9
通讯作者：
C. Proud
中科院分区：
文献类型：
--
作者：
G. Welsh;A. Loughlin;E. Foulstone;N. Price;C. Proud
这些结果与GSK-3本身在胰岛素反应中失活的观点一致，GSK-3可能在elF2B活性的生理调节中发挥关键作用。与这一假设一致的发现是，就像激素和生长因子对GSK-3的抑制一样，elF-2B的激活似乎涉及磷脂酰肌醇3激酶。这些结果为mRNA翻译的调控提供了一种潜在的机制，如下所示
These results are consistent with the idea that GSK-3, which is itself inactivated in the response to insulin, may play a key role in the physiological regulation of elF2B activity. In agreement with this hypothesis is the finding that, like the inhibition of GSK-3 by hormones and growth factors, the activation of elF-2B appears to involve phosphatidyl inositol 3 kinase. These results provide a potential mechanism for the regulation of mRNA translation as shown below