Axonal transport and the cytoskeleton.
Axonal transport and the cytoskeleton.
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DOI：
10.1016/0959-4388(93)90144-n
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发表时间：
1993-10-01
影响因子：
5.7
通讯作者：
Hirokawa, Nobutaka
中科院分区：
文献类型：
--
作者：
Hirokawa, Nobutaka
在过去的一年里，轴突运输领域取得了很大的进展，包括与微管和肌动蛋白相关的新分子马达的鉴定。此外，对双向快速轴突转运机制的研究也阐明了这一过程的新方面，如分离出一种激酶结合蛋白——激酶素，以及发现磷酸化调节激酶素与膜细胞器的分离。研究细胞骨架蛋白缓慢运输的新方法提供了进一步的证据，表明哺乳动物系统中的轴突细胞骨架在很大程度上是静止的，尽管聚合物和一小群移动亚基之间发生了动态交换。
Great advances in the field of axonal transport have been made in the past year, including the identification of new molecular motors associated with microtubules and actin. In addition, studies on the mechanisms of bidirectional fast axonal transport have clarified new aspects of this process, such as the isolation of a kinesin-binding protein, kinectin, and the finding that phosphorylation regulates kinesin's dissociation from membranous organelles. New approaches to studying slow transport of cytoskeletal proteins have provided further evidence that the axonal cytoskeleton in mammalian systems is largely stationary, although a dynamic exchange occurs between polymers and a small pool of moving subunits.