Particle-based technologies for osteoarthritis detection and therapy.
Particle-based technologies for osteoarthritis detection and therapy.
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DOI：
10.1007/s13346-015-0234-2
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发表时间：
2016-04
影响因子：
5.4
通讯作者：
Duvall CL
中科院分区：
文献类型：
--
作者：
Kavanaugh TE;Werfel TA;Cho H;Hasty KA;Duvall CL
Osteoarthritis (OA) is a disease characterized by degradation of joints with the development of painful osteophytes in the surrounding tissues. Currently, there are a limited number of treatments for this disease and many of these only provide temporary, palliative relief. In this review, we discuss polymer drug delivery systems that can provide targeted and sustained delivery of imaging and therapeutic agents to OA-affected sites. We focus on technologies such as polymeric micelles and nano- / micro-particles, liposomes, and dendrimers for their potential treatment and/or diagnosis of OA. Several promising studies are highlighted, motivating the continued development of delivery technologies to improve treatments for OA.
