An electronic application for rapidly calculating Charlson comorbidity score
An electronic application for rapidly calculating Charlson comorbidity score
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DOI：
10.1186/1471-2407-4-94
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发表时间：
2004-12-20
期刊：
影响因子：
3.8
通讯作者：
Vijayakumar, S
中科院分区：
文献类型：
--
作者：
Hall, WH;Ramachandran, R;Vijayakumar, S
背景资料：关于共病的不确定性，以及耐受积极治疗的能力，导致老年癌症患者很少参加临床试验，而且治疗往往不合格。越来越多的共病量表已被证明是有用的，在确定亚组的老年患者谁更有可能耐受和受益于积极的治疗。不幸的是，使用这样的规模还没有被广泛整合到临床实践或临床试验research.Methods：本文回顾了证据的有效性，在肿瘤学的Charlson合并症指数（CCI），并提供了一个Microsoft Excel（MS Excel）宏CCI评分的快速和准确的计算。并发症和恶性疾病的相互作用和验证的Charlson指数在oncology.Results：CCI评分是基于一年的死亡率数据，从内科住院患者入院，是最广泛使用的并发症指数在肿瘤学。使用Microsoft Visual Basic构建MS Excel宏文件以计算CCI评分。CCI已在肿瘤学文献中得到广泛使用和验证，并已证明对大多数主要癌症的实用性。MS Excel CCI Macro提供了一种快速计算CCI分数的方法，可进行或不进行年龄调整。计算器消除了将CCI整合到临床研究中的限制因素，即评分计算困难。MS Excel CCI宏和CCI本身的简单性使其成为集成到新兴的电子医疗记录系统的理想选择。结论：老年人口的增加和肿瘤疾病的并发增加使得了解年龄和共病疾病之间的相互作用对预期寿命的影响越来越重要。MS Excel CCI Macro提供了一种在临床研究中增加CCI量表使用的方法，最终目标是改善老年癌症患者最佳治疗的确定。
Background: Uncertainty regarding comorbid illness, and ability to tolerate aggressive therapy has led to minimal enrollment of elderly cancer patients into clinical trials and often substandard treatment. Increasingly, comorbid illness scales have proven useful in identifying subgroups of elderly patients who are more likely to tolerate and benefit from aggressive therapy. Unfortunately, the use of such scales has yet to be widely integrated into either clinical practice or clinical trials research.Methods: This article reviews evidence for the validity of the Charlson Comorbidity Index (CCI) in oncology and provides a Microsoft Excel (MS Excel) Macro for the rapid and accurate calculation of CCI score. The interaction of comorbidity and malignant disease and the validation of the Charlson Index in oncology are discussed.Results: The CCI score is based on one year mortality data from internal medicine patients admitted to an inpatient setting and is the most widely used comorbidity index in oncology. An MS Excel Macro file was constructed for calculating the CCI score using Microsoft Visual Basic. The Macro is provided for download and dissemination.The CCI has been widely used and validated throughout the oncology literature and has demonstrated utility for most major cancers. The MS Excel CCI Macro provides a rapid method for calculating CCI score with or without age adjustments. The calculator removes difficulty in score calculation as a limitation for integration of the CCI into clinical research. The simple nature of the MS Excel CCI Macro and the CCI itself makes it ideal for integration into emerging electronic medical records systems.Conclusions: The increasing elderly population and concurrent increase in oncologic disease has made understanding the interaction between age and comorbid illness on life expectancy increasingly important. The MS Excel CCI Macro provides a means of increasing the use of the CCI scale in clinical research with the ultimate goal of improving determination of optimal treatments for elderly cancer patients.