Mechanisms of Platelet Activation and Integrin αIIβ3.
Mechanisms of Platelet Activation and Integrin αIIβ3.
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DOI：
10.4070/kcj.2012.42.5.295
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发表时间：
2012-05
影响因子：
2.9
通讯作者：
Joo SJ
中科院分区：
文献类型：
--
作者：
Joo SJ
血小板聚集不仅是止血的重要组成部分，而且可引发急性冠状动脉综合征或缺血性卒中。准确理解血小板聚集的活化机制是开发更有效的抗血小板聚集药物的基础。二磷酸腺苷、凝血酶和血栓烷A2通过G蛋白偶联受体激活血小板整合素αIIbβ3。由Gq、G12/G13或Gi启动的G蛋白介导的信号传导途径包括具有钙信号传导的磷脂酶C、Rho信号传导、蛋白激酶C和磷脂酰肌醇3-激酶。Rap 1b、Ca 2+和二酰基甘油调节的鸟嘌呤核苷酸交换因子I、Rap 1-GTP相互作用接头分子和Akt是参与G蛋白介导的整合素αIIbβ3活化的重要蛋白。talin-1和kindlin-3与β3-整联蛋白胞质结构域的结合引发胞外结构域的构象变化，这增加了其对配体如纤维蛋白原或血管性血友病因子的亲和力。纤维蛋白原作为相邻血小板之间的桥梁，产生血小板聚集体。
Platelet aggregation is not only an essential part of hemostasis, but also initiates acute coronary syndrome or ischemic stroke. The precise understanding of the activation mechanism of platelet aggregation is fundamental for the development of more effective agents against platelet aggregation. Adenosine diphosphate, thrombin, and thromboxane A2 activate platelet integrin αIIbβ3 through G protein-coupled receptors. G protein-mediated signaling pathways, which are initiated by Gq, G12/G13 or Gi, include phospholipase C with calcium signaling, Rho signaling, protein kinase C and phosphatidylinositol 3-kinase. Rap1b, Ca2+ and diacylglycerol-regulated guanine nucleotide exchange factor I, Rap1-GTP-interacting adaptor molecule, and Akt are important proteins involved in G protein-mediated activation of integrin αIIbβ3. Binding of talin-1 and kindlin-3 to cytoplasmic domains of β3-integrin triggers a conformational change in the extracellular domains that increases its affinity for ligands, such as fibrinogen or von Willebrand factor. Fibrinogens act as bridges between adjacent platelets to generate a platelet aggregate.
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影响因子：
20.3
作者：
Braun, Attila;Varga-Szabo, David;Nieswandt, Bernhard
通讯作者：
Nieswandt, Bernhard
影响因子：
2.9
作者：
Lau, Tong-Lay;Partridge, Anthony W.;Ulmer, Tobias S.
通讯作者：
Ulmer, Tobias S.
影响因子：
10.4
作者：
Nieswandt, B.;Varga-Szabo, D.;Elvers, M.
通讯作者：
Elvers, M.
DOI：
10.1084/jem.20071827
发表时间：
2007-12-24
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Nieswandt B;Moser M;Pleines I;Varga-Szabo D;Monkley S;Critchley D;Fässler R
通讯作者：
Fässler R
影响因子：
168.9
作者：
Becker, Richard C.;Moliterno, David J.;Harrington, Robert A.
通讯作者：
Harrington, Robert A.