Colony spreading in Staphylococcus aureus
Colony spreading in Staphylococcus aureus
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DOI：
10.1128/jb.01635-06
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发表时间：
2007-03-01
影响因子：
3.2
通讯作者：
Sekimizu, Kazuhisa
中科院分区：
文献类型：
--
作者：
Kaito, Chikara;Sekimizu, Kazuhisa
野生型金黄色葡萄球菌在软琼脂平板表面迅速扩增。实验室储备和临床分离株的不同菌株的扩增速率和所产生的巨大菌落的形状是不同的。这些菌株的殖民地扩展能力与生物膜形成能力无关。dltABCD操纵子和tagO基因的插入破坏降低了殖民地扩展能力，dltABCD操纵子在D-丙氨酸添加到磷壁酸的步骤中起作用，tagO基因负责壁磷壁酸的合成。结果表明，壁磷壁酸和磷壁酸的D-丙氨酰化是菌落扩展所必需的。
Wild-type Staphylococcus aureus rapidly expands on the surface of soft agar plates. The rates of expansion and the shapes of the resultant giant colonies were distinct for different strains of laboratory stocks and clinical isolates. The colony spreading abilities did not correlate with the biofilm-forming abilities in these strains. Insertional disruption of the dltABCD operon, which functions at the step Of D-alanine addition to teichoic acids, and of the tagO gene, which is responsible for the synthesis of wall teichoic acids, decreased the colony spreading ability. The results indicate that wall teichoic acids and D-alanylation of teichoic acids are required for colony spreading.