Visual outcome correlates with inner macular volume in eyes with surgically closed macular hole.
Visual outcome correlates with inner macular volume in eyes with surgically closed macular hole.
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DOI：
10.1097/iae.0b013e31825c1c0c
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发表时间：
2012-11
期刊：
影响因子：
--
通讯作者：
Park SS
中科院分区：
文献类型：
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作者：
Pilli S;Zawadzki RJ;Werner JS;Park SS
确定手术闭合的特发性黄斑裂孔眼的黄斑形态学特征与视力结果最相关。术后使用高分辨率傅立叶域光学相干断层扫描（FD-OCT）成像的24只眼（22例受试者）的经皮观察病例系列。中心凹厚度、中心凹内段-外段交界处异常的大小与最佳矫正视力相关。在18只眼睛的子集中进行微视野（MP-1）测试。平均术后最佳矫正视力为20/36（范围：20/25-20/70）。术后平均随访时间为32.97 ± 24.68个月（范围：5-96个月）。18只眼行内界膜（ILM）剥离术。在FD-OCT参数中，最小分辨角、最佳矫正视力和平均总微视野-1灵敏度的对数与所有眼和ILM剥离眼的黄斑内体积相关性最好（P < 0.05）。12只（66.7%）ILM剥离眼出现黄斑表面不规则，而非ILM剥离眼无黄斑表面不规则（P = 0.02）。微视野-1灵敏度与其他FD-OCT参数之间无显著相关性。由于手术闭合黄斑裂孔的患者黄斑内容积与视力结果密切相关，因此需要进一步研究ILM剥离对视力结果的可能影响。
To determine the macular morphologic features that correlate best with visual outcome in eyes with surgically closed idiopathic macular hole. Transversal observational case series of 24 eyes (22 subjects) imaged postoperatively using high-resolution Fourier domain optical coherence tomography (FD-OCT). Total and inner macular volume for central 3 mm area, central foveal thickness, and size of foveal inner segment–outer segment junction abnormality were correlated with best-corrected visual acuity. Microperimetry (MP-1) test was performed in a subset of 18 eyes. Mean postoperative best-corrected visual acuity was 20/36 (range, 20/25–20/70). Postoperative follow-up mean was 32.97 ± 24.68 months (range, 5–96 months). Eighteen eyes underwent internal limiting membrane (ILM) peeling. Among FD-OCT parameters, logarithm of the minimum angle of resolution best-corrected visual acuity and mean total microperimetry-1 sensitivity correlated best with inner macular volume in all eyes and ILM-peeled eyes (P < 0.05). Macular surface irregularities were noted in 12 eyes (66.7%) with ILM peeling but in none of the non–ILM-peeled eyes (P = 0.02). No significant correlation was found between microperimetry-1 sensitivity and other FD-OCT parameters. Because inner macular volume strongly correlated with visual outcome in eyes with surgically closed macular hole, the possible effect of ILM peeling on visual outcome needs to be further investigated.