Immunotherapy beyond cellular therapy in follicular lymphoma: A case of complete remission after failure of two CAR-T.

Immunotherapy beyond cellular therapy in follicular lymphoma: A case of complete remission after failure of two CAR-T.
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DOI:
10.1002/ccr3.5572
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发表时间:
2022-04
影响因子:
0.7
通讯作者:
Sher T
Sher T
中科院分区:
其他
文献类型:
--
作者:
Kase AM;Kharfan-Dabaja MA;Donaldson A;Elliott J;Sher T

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CAR - T治疗无效的复发性滤泡性淋巴瘤患者预后较差。我们报告了一例难治性滤泡性淋巴瘤,他在两次CAR - T输注后复发,并在使用obinutuzumab和来那度胺治疗后完全缓解。这代表了CAR - T后治疗的一个有希望的选择。对于CAR - T治疗后进展的难治性滤泡性淋巴瘤患者,应考虑来那度胺加比努单抗。
Patients with relapsed follicular lymphoma who do not respond to CAR‐T have a poor outcome. We present a case of refractory follicular lymphoma who relapsed after two CAR‐T infusions and achieved a complete remission after treatment with obinutuzumab and lenalidomide. This represents a promising treatment option in the post‐CAR‐T setting. Lenalidomide plus obinutuzumab should be considered in patients with refractory follicular lymphoma who progress after CAR‐T.
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