Chapter 2: Kill the bacteria...and also their messengers?
Chapter 2: Kill the bacteria...and also their messengers?
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DOI：
10.1016/s0065-2776(09)03002-8
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发表时间：
2009
影响因子：
--
通讯作者：
Varley, Alan
中科院分区：
文献类型：
--
作者：
Munford, Robert;Lu, Mingfang;Varley, Alan
我们在这里考虑以前被忽视的传染病恢复方面：动物如何处理组织中死亡的微生物。对于最重要的致病微生物之一——革兰氏阴性菌来说，现在有证据表明，宿主对关键微生物分子的分解代谢对于完全恢复至关重要。正如所料，动物通过感知来检测其组织中是否存在革兰氏阴性细菌，即细胞壁脂多糖（LPS）。在这里，我们讨论有关 LPS 传感的最新知识，重点是使这种微生物“信使”分子失活的宿主酶。我们还考虑了刺激性微生物分子失活的速度可能会影响其他传染源引起的疾病的持续时间和严重程度的可能性。
We consider here a previously neglected aspect of recovery from infectious diseases: how animals dispose of the dead microbes in their tissues. For one of the most important disease-causing microorganisms, Gram-negative bacteria, there is now evidence that the host catabolism of a key microbial molecule is essential for full recovery. As might be expected, it is the same bacterial molecule that animals sense to detect the presence of Gram-negative bacteria in their tissues, the cell wall lipopolysaccharide (LPS). Here, we discuss current knowledge about LPS sensing with emphasis on the host enzyme that inactivates this microbial “messenger” molecule. We also consider the possibility that the rate at which stimulatory microbial molecules undergo inactivation may influence the duration and severity of diseases caused by other infectious agents.