Functional lipidomics: the roles of specialized lipids and lipid-protein interactions in modulating neuronal function
Functional lipidomics: the roles of specialized lipids and lipid-protein interactions in modulating neuronal function
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DOI：
10.1016/j.prostaglandins.2004.09.005
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发表时间：
2005-09-01
影响因子：
2.9
通讯作者：
Han, XL
中科院分区：
文献类型：
--
作者：
Gross, RW;Jenkins, CM;Han, XL
脂质在神经元功能中发挥多种专门作用。在大脑中，电脉冲的传导、突触功能和复杂的信号传导通路取决于特定脂质（例如，花生四烯酸和缩醛磷脂），蛋白质（例如，离子通道、磷脂酶和环加氧酶）和整合的脂质-蛋白质相互作用。最近质谱技术的进步使人们对脂质在神经元功能中的作用有了前所未有的了解。通过鸟枪脂质组学和多维质谱法，结合新类型磷脂酶的鉴定（例如，钙依赖性和钙非依赖性细胞内磷脂酶），脂质在脑功能中的新作用已经积累。这篇综述总结了我们对大脑中脂质和磷脂酶类型的理解以及功能脂质组学在增加我们对复杂神经过程的化学理解中的作用。(c)2004年爱思唯尔公司All rights reserved.
Lipids fulfill multiple specialized roles in neuronal function. In brain, the conduction of electrical impulses, synaptic function, and complex signaling pathways depend on the temporally and spatially coordinated interactions of specialized lipids (e.g., arachidonic acid and plasmalogens), proteins (e.g., ion channels, phospholipases and cyclooxygenases) and integrative lipid-protein interactions. Recent technical advances in mass spectrometry have allowed unparalled insight into the roles of lipids in neuronal function. Through shotgun lipidomics and multidimensional mass spectrometry, in conjunction with the identification of new classes of phospholipases (e.g., calcium dependent and calcium independent intracellular phospholipases), new roles for lipids in cerebral function have been accrued. This review summarizes the advances in our understanding of the types of lipids and phospholipases in the brain and the role of functional lipidomics in increasing our chemical understanding of complex neuronal processes. (c) 2004 Elsevier Inc. All rights reserved.