Experimental Models of Stress and Pain: Do They Help to Develop New Therapies?
Experimental Models of Stress and Pain: Do They Help to Develop New Therapies?
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DOI：
10.1159/000268122
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发表时间：
2009-01-01
影响因子：
2.3
通讯作者：
Mayer, Emeran A.
中科院分区：
文献类型：
--
作者：
Bradesi, Sylvie;Mayer, Emeran A.
大多数功能性胃肠道疾病的特征是反复发作的腹痛，压力在现有症状的首次发作和恶化中起着重要作用。这些疾病目前是由症状标准定义的，而其病理生理学仍然存在争议和不完全理解。在人类和动物中模拟这些疾病一直很困难。虽然一些模型具有足够的表面和结构效度，但大多数模型的预测效度令人失望，这对传统的建模方法提出了质疑。在疼痛和精神疾病的药物开发中也遇到了类似的问题。已经以反向翻译的形式提出了新的方法，其包括可以在人类和动物中建模的人类疾病中的生物中间表型的更好表征。继续目前的方法，重点是复杂的临床表型可能是无效的新的和有效的治疗方法的发展。版权所有（C）2010 S. Karger AG，巴塞尔
The majority of functional gastrointestinal disorders are characterised by recurrent abdominal pain, with stress playing an important role in first onset and exacerbation of existing symptoms. These disorders are currently defined by symptom criteria, while their pathophysiology remains controversial and incompletely understood. Modeling these disorders in humans and animals has been difficult. While some of the models have adequate face and construct validity, the predictive validity of most of the models has been disappointing, which has put into question the traditional modeling approach. Similar problems have been encountered in drug development for pain and psychiatric disorders. New approaches have been proposed in the form of reverse translation, which include better characterisation of biological intermediate phenotypes in human disease which can be modeled in humans and in animals. Continuation of the current approach focusing on complex clinical phenotypes is likely to be ineffective for the development of novel and effect treatments. Copyright (C) 2010 S. Karger AG, Basel