Knee osteoarthritis: Clinical connections to articular cartilage structure and function
Knee osteoarthritis: Clinical connections to articular cartilage structure and function
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DOI：
10.1016/j.ptsp.2014.12.001
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发表时间：
2015-11-01
影响因子：
2.4
通讯作者：
Brody, Lori Thein
中科院分区：
文献类型：
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作者：
Brody, Lori Thein
关节软骨是一种独特的双相材料，可在整个关节内承受压缩力和剪切力。当关节软骨恶化时，无论是由于损伤、磨损还是正常老化，骨关节炎和由此产生的疼痛都可能随之而来。了解关节软骨的结构和生物力学的基础科学可以帮助临床医生指导他们的患者进行适当的活动和负荷选择。本文的目的是研究关节软骨的结构和力学，可能与风险因素相互作用，以促进OA，以及这种相互作用如何为干预选择提供指导。本文将回顾关节软骨的微观结构，其机械性能，并将此信息与临床决策联系起来。(C)2014爱思唯尔有限公司版权所有。
Articular cartilage is a unique biphasic material that supports a lifetime of compressive and shear forces across joints. When articular cartilage deteriorates, whether due to injury, wear and tear or normal aging, osteoarthritis and resultant pain can ensue. Understanding the basic science of the structure and biomechanics of articular cartilage can help clinicians guide their patients to appropriate activity and loading choices. The purpose of this article is to examine how articular cartilage structure and mechanics, may interact with risk factors to contribute to OA and how this interaction provides guidelines for intervention choices This paper will review the microstructure of articular cartilage, its mechanical properties and link this information to clinical decision making. (C) 2014 Elsevier Ltd. All rights reserved.