Mixed Lineage Kinase-c-Jun N-Terminal Kinase Axis: A Potential Therapeutic Target in Cancer.
Mixed Lineage Kinase-c-Jun N-Terminal Kinase Axis: A Potential Therapeutic Target in Cancer.
复制标题
DOI：
10.1177/1947601913485415
复制
发表时间：
2013-09-01
期刊：
影响因子：
--
通讯作者：
Kanthasamy, Anumantha
中科院分区：
文献类型：
--
作者：
Rana, Ajay;Rana, Basabi;Kanthasamy, Anumantha
混合谱系激酶（MLK）是丝裂原活化蛋白激酶（MAP3K）家族的成员，并且据报道激活MAP激酶途径。迄今为止，已经确定了至少9个MLK家族成员，尽管所有家族成员的生理功能尚不清楚。然而，MLK通常涉及神经退行性疾病，包括帕金森病和阿尔茨海默病。最近的报道表明，MLK的一些成员可以通过调节细胞迁移，侵袭，细胞周期和凋亡在癌症中发挥作用。这篇综述文章将首先描述MLK成员的生物学，然后讨论与其在癌症中的功能相关的当前进展。
Mixed lineage kinases (MLKs) are members of the mitogen-activated protein kinase kinase kinase (MAP3K) family and are reported to activate MAP kinase pathways. There have been at least 9 members of the MLK family identified to date, although the physiological functions of all the family members are yet unknown. However, MLKs in general have been implicated in neurodegenerative diseases, including Parkinson and Alzheimer diseases. Recent reports suggest that some of the MLK members could play a role in cancer via modulating cell migration, invasion, cell cycle, and apoptosis. This review article will first describe the biology of MLK members and then discuss the current progress that relates to their functions in cancer.