Dexamethasone suppression testing of alcoholics.
Dexamethasone suppression testing of alcoholics.
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酗酒者的地塞米松抑制试验。
DOI：
10.1001/archpsyc.1982.04290110061010
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发表时间：
1982
影响因子：
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通讯作者：
F. Dunner
中科院分区：
文献类型：
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作者：
C. Swartz;F. Dunner
43名因酒精滥用住院的男性中，14名（33%）在给予1毫克地塞米松17小时后（入院后5天）下午4点出现皮质醇水平异常。大多数（但不是全部）这些非抑制者表现出酒精性身体恶化的多种迹象；酒精滥用可能有不止一种机制导致该测试的异常结果。抑制者和非抑制者报告相似的饮酒、抑郁症状和近亲中抑郁的发生。只有两名患者（5%）在给予地塞米松治疗9小时后，即上午8点出现皮质醇水平异常。这些结果表明，作为对最近戒酒的酒精滥用者的原发性抑郁症的筛查，下午4点的皮质醇水平不够具体，但早上8点的皮质醇水平可能对没有酗酒亲属的患者有用。
Fourteen (33%) of 43 men hospitalized for alcohol abuse showed abnormal cortisol levels at 4 pm, 17 hours after administration of 1 mg of dexamethasone (median, five days after admission). Most (but not all) of these nonsuppressors showed multiple signs of alcoholic physical deterioration; there may be more than one mechanism by which alcohol abuse can lead to an abnormal result of this test. Suppressors and nonsuppressors reported similar alcohol consumption, symptoms of depression, and occurrence of depression among close relatives. Only two patients (5%) showed abnormal cortisol levels at 8 am, nine hours after administration of dexamethasone. These results suggest that, as a screen for primary depressive illness among recently abstinent alcohol abusers, the 4 pm cortisol level is not specific enough, but the 8 am level might be useful in patients who have no alcoholic relatives.
影响因子：
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作者：
L. Robins;J. Helzer;J. Croughan;K. Ratcliff
通讯作者：
L. Robins;J. Helzer;J. Croughan;K. Ratcliff