CELL-MEDIATED-IMMUNITY AS A PREDICTOR OF MORBIDITY AND MORTALITY IN SUBJECTS OVER 60
CELL-MEDIATED-IMMUNITY AS A PREDICTOR OF MORBIDITY AND MORTALITY IN SUBJECTS OVER 60
复制标题
DOI：
10.1093/geronj/45.2.m45
复制
发表时间：
1990-03-01
期刊：
影响因子：
--
通讯作者：
GOODWIN, JS
中科院分区：
文献类型：
--
作者：
WAYNE, SJ;RHYNE, RL;GOODWIN, JS
Previous studies have suggested an association between depressed cell-mediated immunity and increased mortality in elderly persons.However, the effects of age and existing disease on this association have not been adequately addressed.We studied the association between cell-mediated immunity and subsequent morbidity and mortality in 273 initially healthy persons 60 years of age and older.In 1979, two tests of cell-mediated immunity were conducted —mitogen stimulation with phytohaemagglutinin, and delayed hypersensitivity skin testing.The study group was followed annually for development of pneumonia, cancer, and death.Anergy was associated with all-cause mortality (hazard ratio of 2.16; 95% confidence interval [1.10,4.28]).When the results were adjusted for age, the resulting hazard ratio was 1.89;[0.94,3.79].A relationship was also suggested between anergy and cancer mortality although this association was not statistically significant.Response to phytohaemagglutinin was a poorer predictor of mortality than was response to delayed hypersensitivity skin testing.The results show that anergy may be a good indicator of subsequent all-cause mortality, and perhaps cancer mortality, in elderly who lack other indicators of poor health.
