3D Bioelectronics with a Remodellable Matrix for Long-Term Tissue Integration and Recording.
3D Bioelectronics with a Remodellable Matrix for Long-Term Tissue Integration and Recording.
复制标题
具有可重塑矩阵的 3D 生物电子学，用于长期组织整合和记录。
DOI：
10.1002/adma.202207847
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Boys AJ
中科院分区：
文献类型：
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作者：
Boys AJ
生物电子学是理解和治疗疾病的关键。然而，在电子设备和身体之间实现稳定、长期的接口仍然是一个挑战。生物电子设备的植入通常会引发异物反应，这可能会限制长期记录和刺激功效。来自再生医学的技术已经显示出促进植入物与周围组织整合的高倾向，但是这些植入物缺乏由电子器件提供的复杂记录和致动的能力。结合这两个领域可以实现两全其美。此处显示了用于与组织形成长期界面的混合植入物系统的构造。植入物是通过将微电极阵列与生物可吸收和可重塑的凝胶相结合而形成的。这些植入物被证明在植入肌肉组织时产生最小的异物反应，允许人们以高空间分辨率记录长期肌电信号。该设备平台推动了新一代植入式电子设备用于长期接口的可能性。
Bioelectronics hold the key for understanding and treating disease. However, achieving stable, long‐term interfaces between electronics and the body remains a challenge. Implantation of a bioelectronic device typically initiates a foreign body response, which can limit long‐term recording and stimulation efficacy. Techniques from regenerative medicine have shown a high propensity for promoting integration of implants with surrounding tissue, but these implants lack the capabilities for the sophisticated recording and actuation afforded by electronics. Combining these two fields can achieve the best of both worlds. Here, the construction of a hybrid implant system for creating long‐term interfaces with tissue is shown. Implants are created by combining a microelectrode array with a bioresorbable and remodellable gel. These implants are shown to produce a minimal foreign body response when placed into musculature, allowing one to record long‐term electromyographic signals with high spatial resolution. This device platform drives the possibility for a new generation of implantable electronics for long‐term interfacing.