Maturation of human central auditory system activity: separating auditory evoked potentials by dipole source modeling
Maturation of human central auditory system activity: separating auditory evoked potentials by dipole source modeling
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DOI：
10.1016/s1388-2457(01)00733-7
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发表时间：
2002-03-01
影响因子：
4.7
通讯作者：
Don, M
中科院分区：
文献类型：
--
作者：
Ponton, C;Eggermont, JJ;Don, M
目的：以往的研究表明，观察到的听觉诱发电位（AEP）的成熟模式取决于头皮记录电极的位置。偶极源建模结合了在所有电极位置记录的AEP信息。这应该提供一个更强大的描述听觉系统成熟的基础上年龄相关的变化AEP。因此，本研究的目的是评估中央听觉系统的成熟度为基础的偶极子建模的多电极长潜伏期AEPs recording.Methods：AEPs记录在30头皮电极位置从118名受试者之间的5和20岁。区域偶极子源分析，使用对称定位的源，被用来产生一个时空源模型的年龄相关的变化AEP潜伏期和magnitude. Results：区域偶极子源模型分离的AEP到不同的组，这取决于组件偶极子的方向。矢状定向偶极子源包含两个AEP峰，与中潜伏期反应（MLR）的Pa和Pb潜伏期相当。虽然一些幅度的变化，注意到，Pa和Pb的lavonium没有表现出与年龄相关的变化的证据。切向源含有与P-1、N-1b和P-2相当的活性。切线源中AEP的潜伏期和幅度存在各种与年龄相关的变化。放射状取向的源包含与T复合物相当的活性，包括Ta和Tb，其仅显示出随年龄的小的潜伏期变化。此外，标记TP200的长潜伏期组件observed.Conclusions：它是可以区分3个成熟组：一组在6岁时达到成熟，包括MLR组件Pa和Pb，P-2，和T-复合体。第二组成熟相对较快（50%/年），以N-2为代表。第三组的特征是成熟模式较慢，速度为11 - 17%/年，包括AEP峰Pi，Nib和TP 200。观察到的潜伏期差异与成熟率的差异相结合，表明P2与TP 200不相同。结果还表明，T-复杂的成分，代表在径向偶极子，从P-1，N-1b，和P-2分量，包含在切向定向偶极子源的独立性。(C)2002爱思唯尔科学爱尔兰有限公司保留所有权利。
Objectives: Previous studies have shown that observed patterns of auditory evoked potential (AEP) maturation depend on the scalp location of the recording electrodes. Dipole source modeling incorporates the AEP information recorded at all electrode locations. This should provide a more robust description of auditory system maturation based on age-related changes in AEPs. Thus, the purpose of this study was to evaluate central auditory system maturation based dipole modeling of multi-electrode long-latency AEPs recordings.Methods: AEPs were recorded at 30 scalp-electrode locations from 118 subjects between 5 and 20 years of age. Regional dipole source analysis, using symmetrically located sources, was used to generate a spatio-temporal source model of age-related changes in AEP latency and magnitude.Results: The regional dipole source model separated the AEPs into distinct groups depending on the orientation of the component dipoles. The sagittally oriented dipole sources contained two AEP peaks, comparable in latency to Pa and Pb of the middle latency response (MLR). Although some magnitude changes were noted, latencies of Pa and Pb showed no evidence of age-related change. The tangentially oriented sources contained activity comparable to P-1, N-1b, and P-2. There were various age-related changes in the latency and magnitude of the AEPs represented in the tangential sources. The radially oriented sources contained activity comparable to the T-complex, including Ta, and Tb, that showed only small latency changes with age. In addition, a long-latency component labeled TP200 was observed.Conclusions: It is possible to distinguish 3 maturation groups: one group reaching maturity at age 6 and comprising the MLR components Pa and Pb, P-2, and the T-complex. A second group that was relatively fast to mature (50%/year) was represented by N-2. A third group was characterized by a slower pattern of maturation with a rate of 11-17%/year and included the AEP peaks Pi, Nib, and TP200. The observed latency differences combined with the differences in maturation rate indicate that P2 is not identical to TP200. The results also demonstrated the independence of the T-complex components, represented in the radial dipoles, from the P-1, N-1b, and P-2 components, contained in the tangentially oriented dipole sources. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.