Structural brain abnormalities in adult males with clefts of the lip and/or palate
Structural brain abnormalities in adult males with clefts of the lip and/or palate
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DOI：
10.1097/00125817-200201000-00001
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发表时间：
2002-01-01
影响因子：
8.8
通讯作者：
Andreasen, NC
中科院分区：
文献类型：
--
作者：
Nopoulos, P;Berg, S;Andreasen, NC
目的：评价成年男性非综合征性唇腭裂(NSCLP)患者的脑组织形态，并与健康对照组进行比较。方法：采用磁共振图像定量分析方法对脑结构进行测量。结果：NSCLP患者存在明显的脑形态异常改变，表现为大脑前部异常增大，大脑后部和小脑体积缩小。总体而言，受影响最严重的区域是左侧颞叶。此外，这些结构异常与认知功能障碍直接相关。结论：这些发现突出了脸部和大脑发育之间的重要关系和相互作用。
Purpose: To evaluate brain morphology of adult males with nonsyndromic clefts of the lip and/or palate (NSCLP) in comparison to a matched healthy control group. Methods: Brain structure was measured using quantitative analysis of magnetic resonance images. Results: Subjects with NSCLP had significant abnormalities in brain morphology consisting of abnormally enlarged anterior regions of the cerebrum, and decreased volumes of the posterior cerebrum and cerebellum. Overall, the most severely affected region was the left temporal lobe. Furthermore, these structural abnormalities were directly related to cognitive dysfunction. Conclusions: These findings highlight the important relationship and interplay between face and brain development.