The effect of ISP and PAP4 peptides treatment on the functional motor recovery in rat following spinal ventral root injury.
The effect of ISP and PAP4 peptides treatment on the functional motor recovery in rat following spinal ventral root injury.
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发表时间：
2020
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通讯作者：
Wutian Wu
中科院分区：
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作者：
Shi-Qin Lv;Wutian Wu
Both intracellular sigma peptide (ISP) and phosphatase and tensin homolog agonist protein (PAP4) promote nerve regeneration and motor .functional recovery after spinal cord injury. However, the role of these two small peptides in peripheral nerve injury remains unclear. A rat .model of brachial plexus injury was established by crush of the C6 ventral root. The rats were then treated with subcutaneous injection of .PAP4 (497 µg/d, twice per day) or ISP (11 µg/d, once per day) near the injury site for 21 successive days. After ISP and PAP treatment, the .survival of motoneurons was increased, the number of regenerated axons and neuromuscular junctions was increased, muscle atrophy was .reduced, the electrical response of the motor units was enhanced and the motor function of the injured upper limbs was greatly improved in .rats with brachial plexus injury. These findings suggest that ISP and PAP4 promote the recovery of motor function after peripheral nerve injury .in rats.
