Increased corticospinal excitability after 5Hz rTMS over the human supplementary motor area
Increased corticospinal excitability after 5Hz rTMS over the human supplementary motor area
复制标题
DOI：
10.1113/jphysiol.2004.070755
复制
发表时间：
2005-01-01
影响因子：
5.5
通讯作者：
Rothwell, JC
中科院分区：
文献类型：
--
作者：
Matsunaga, K;Maruyama, A;Rothwell, JC
经颅磁刺激（TMS）不仅可以在刺激部位产生效应，还可以在其投射的远距离部位产生效应。在这里，我们研究了补充运动区（SMA）和初级运动皮层（M1（手））的手区之间的连接，通过测试是否延长重复TMS（rTMS）在SMA可以产生刺激序列结束后的M1（手）的兴奋性的变化。我们评估了运动诱发电位（MEP）和皮层沉默期（CSP）引起的单脉冲TMS，短间隔皮层内抑制（SICI）和皮层内促进（ICF）产生的配对脉冲TMS，和前臂屈肌H反射之前和之后的750个脉冲的5 Hz rTMS超过SMA在110%的主动运动阈值（AMT）的强度为第一背侧骨间（FDI）肌肉。记录从右FDI肌肉在休息时，以及在自愿收缩的幅度增加至少10分钟后结束的rTMS，虽然CSP，SICI和ICF的持续时间没有改变。在桡侧腕屈肌的H反射没有影响，即使从同一肌肉获得的MEP的幅度增加后rTMS。对MEP的影响取决于rTMS的强度，并在空间上特定于SMA。我们认为，5 Hz rTMS在SMA上可以诱导一个短暂的促进M I手的兴奋性与SMA和M1（手）之间的解剖连接兼容。
Transcranial magnetic stimulation (TMS) can produce effects not only at the site of stimulation but also at distant sites to which it projects. Here we examined the connection between supplementary motor area (SMA) and the hand area of the primary motor cortex (M1(Hand)) by testing whether prolonged repetitive TMS (rTMS) over the SMA can produce changes in excitability of the M1(Hand) after the end of the stimulus train. We evaluated motor-evoked potentials (MEPs) and the cortical silent period (CSP) evoked by a single-pulse TMS, short-interval intracortical inhibition (SICI) and intracortical facilitation (ICF) produced by a paired-pulse TMS, and forearm flexor H reflexes before and after 750 pulses of 5 Hz rTMS over SMA at an intensity of 110% active motor threshold (AMT) for the first dorsal interosseous (FDI) muscle. The amplitude of MEPs recorded from the right FDI muscle at rest as well as during voluntary contraction increased for at least 10 min after the end of rTMS, although the duration of the CSP, SICI and ICF did not change. There was no effect on H reflexes in the flexor carpi radialis muscle, even though the amplitude of the MEP obtained from the same muscle increased after rTMS. The effects on MEPs depended on the intensity of rTMS and were spatially specific to the SMA proper. We suggest that 5 Hz rTMS over SMA can induce a short-lasting facilitation in excitability of the M I Hand compatible with the anatomical connections between SMA and the M1(Hand).