Association between insulin resistance and post-ischaemic stroke outcome in patients without diabetes: protocol for a systematic review and meta-analysis.
Association between insulin resistance and post-ischaemic stroke outcome in patients without diabetes: protocol for a systematic review and meta-analysis.
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DOI：
10.1136/bmjopen-2020-044771
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发表时间：
2021-03-26
期刊：
影响因子：
2.9
通讯作者：
Shamy M
中科院分区：
文献类型：
--
作者：
Hadwen J;Kim W;Dewar B;Ramsay T;Davis A;Dowlatshahi D;Shamy M
胰岛素抵抗是动脉粥样硬化、冠状动脉疾病和缺血性中风的独立危险因素。目前，胰岛素抵抗通常不包括在卒中后风险分层中。本系统综述和荟萃分析旨在确定现有科学知识是否支持胰岛素抵抗与非糖尿病患者卒中后预后之间的关联。作者将在Medline， Embase， Web of Science和Cochrane Central进行文献检索。该综述将包括评估胰岛素抵抗胰岛素稳态模型升高（HOMA-IR）与卒中后结局（功能结局和卒中复发）之间关系的研究。将使用系统评价和荟萃分析（PRISMA）报告指南的首选报告项目。主要终点是卒中后功能终点（改良Rankin量表），次要终点是缺血性卒中复发。将比较最高和最低HOMA-IR范围（如本系统综述中每篇文章所定义）的结果。将对偏倚风险进行定性评估。如果研究之间存在足够的同质性，将进行荟萃分析。结果的异质性用I²来评估。没有使用人类或动物受试者或样本。研究结果将发表在同行评议的期刊上，并将在当地和国际神经病学会议上传播。CRD42020173608。
Insulin resistance is an independent risk factor for atherosclerosis, coronary artery disease and ischaemic stroke. Currently, insulin resistance is not usually included in post-stroke risk stratification. This systematic review and meta-analysis intends to determine if available scientific knowledge supports an association between insulin resistance and post-stroke outcomes in patients without diabetes. The authors will conduct a literature search in Medline, Embase, Web of Science and Cochrane Central. The review will include studies that assess the association between elevated insulin homeostasis model of insulin resistance (HOMA-IR) and post-stroke outcome (functional outcome and recurrent stroke). The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) reporting guidelines will be used. The primary outcome will be post-stroke functional outcome (Modified Rankin Scale), and the secondary outcome will be recurrent ischaemic stroke. Comparison of outcome will be made between highest and lowest HOMA-IR range (as defined in each article included in this systematic review). Risk of bias will be assessed qualitatively. Meta-analysis will be performed if sufficient homogeneity exists between studies. Heterogeneity of outcomes will be assessed by I². No human or animal subjects or samples were/will be used. The results will be published in a peer-reviewed journal, and will be disseminated at local and international neurology conferences. CRD42020173608.
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DOI：
10.3233/jrs-120581
发表时间：
2013-01-01
期刊：
The International journal of risk & safety in medicine
影响因子：
--
作者：
Marks, Donald H
通讯作者：
Marks, Donald H
DOI：
10.1136/bmj.b2535
发表时间：
2009-07-21
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Moher D;Liberati A;Tetzlaff J;Altman DG;PRISMA Group
通讯作者：
PRISMA Group
DOI：
10.1136/bmj.e3564
发表时间：
2012-06-07
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Lee M;Saver JL;Hong KS;Song S;Chang KH;Ovbiagele B
通讯作者：
Ovbiagele B
胰岛素抵抗的稳态模型评估与缺血性中风的非糖尿病患者不良功能结果的关系
影响因子：
4
作者：
Li, Siou;Yin, Changhao;Qiao, Hong
通讯作者：
Qiao, Hong
影响因子：
6.1
作者：
Ntaios, G.;Milionis, H.;Papavasileiou, V.
通讯作者：
Papavasileiou, V.