Mitochondrial biofuel cells: expanding fuel diversity to amino acids
Mitochondrial biofuel cells: expanding fuel diversity to amino acids
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DOI：
10.1039/c0cp01362e
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发表时间：
2011-01-01
影响因子：
3.3
通讯作者：
Minteer, Shelley D.
中科院分区：
文献类型：
--
作者：
Bhatnagar, Dushyant;Xu, Shuai;Minteer, Shelley D.
虽然线粒体长期以来一直被认为是活细胞的发电站，但直到最近，我们才能够在电化学能量转换装置中使用这些细胞器进行电催化。使用生物实体进行能量转换的概念，通常称为生物燃料电池，已经研究了近世纪，但是直到最近，生物实体仅限于微生物或分离的酶。然而，从有效的能量转换和高体积催化活性的角度来看，线粒体可能是微生物燃料电池的效率和酶生物燃料电池的高体积催化活性之间的一种可能的折衷。这种观点的重点是比较线粒体生物燃料电池与其他类型的生物燃料电池，以及研究可用于线粒体生物燃料电池的燃料多样性。丙酮酸和脂肪酸以前曾被研究作为燃料，但这一观点表明，氨基酸也可以作为燃料。
Although mitochondria have long been considered the powerhouse of the living cell, it is only recently that we have been able to employ these organelles for electrocatalysis in electrochemical energy conversion devices. The concept of using biological entities for energy conversion, commonly referred to as a biofuel cell, has been researched for nearly a century, but until recently the biological entities were limited to microbes or isolated enzymes. However, from the perspectives of efficient energy conversion and high volumetric catalytic activity, mitochondria may be a possible compromise between the efficiency of microbial biofuel cells and the high volumetric catalytic activity of enzymatic biofuel cells. This perspective focuses on comparing mitochondrial biofuel cells to other types of biofuel cells, as well as studying the fuel diversity that can be employed with mitochondrial biofuel cells. Pyruvate and fatty acids have previously been studied as fuels, but this perspective shows evidence that amino acids can be employed as fuels as well.