Relationships between plasma adiponectin and blood cells, hepatopancreatic enzymes in women
Relationships between plasma adiponectin and blood cells, hepatopancreatic enzymes in women
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DOI：
10.1160/th03-04-0256
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发表时间：
2004-02-01
影响因子：
6.7
通讯作者：
Katayose, S
中科院分区：
文献类型：
--
作者：
Matsubara, M;Namioka, K;Katayose, S
脂联素是由脂肪细胞特异性分泌的，被认为在代谢综合征中发挥着关键作用。我们研究了 339 名 54.0 +/- 岁女性的血浆脂联素浓度与血细胞和肝胰酶的关系。 0.8（平均值 +/- SE）年。与非贫血受试者 (471.1 +/- 1.7) 相比，轻微贫血女性在调整身体成分或计算出的胰岛素抵抗前后血浆脂联素增加 (372.6 +/- 2.6 X 10(4)/mm(3))（所有 p < 0.0001），并且与红细胞 (RBC)、血红蛋白、血细胞比容、白细胞和血小板值呈负相关 (p < 0.0001 与 0.02 相似），与年龄、舒张压、体重指数、血清甘油三酯、胰岛素抵抗或血尿素氮无关。在逐步回归分析中，年龄和脂联素/体脂量（%）为负，血压和胰岛素抵抗为红细胞的正显着独立决定因素。此外，调整前后的脂联素与血清 ALAT、gammaGTP 和 ChE 呈负相关，与淀粉酶水平呈正相关（p < 0.0001 与 0.02 相似）。这些结果表明增加的脂联素可能有助于体内抑制骨髓功能。结合瘦素的数据，脂肪细胞衍生的蛋白质与造血有关，因此更清楚地表明脂肪组织/骨髓功能联动的可能存在。此外，肝胰酶与该蛋白质的关联可能表明脂联素可能在健康和疾病中调节肝胰功能。
Adiponectin, which is secreted specifically from adipocyte, is thought to play a key role in the metabolic syndrome. We studied the associations of plasma adiponectin concentrations with blood cells and hepatopancreatic enzymes in 339 women aged 54.0 +/-. 0.8 (mean +/- SE) years. Plasma adiponectin before and after adjustment for body composition or calculated insulin resistance increased in slight anemic women (372.6 +/- 2.6 X 10(4)/mm(3)) compared with non-anemic subjects (471.1 +/- 1.7) (all p < 0.0001), and were inversely associated with red blood cells (RBC), hemoglobin, hematocrit, white blood cells and platelet values (p < 0.0001 similar to 0.02), independent of age, diastolic blood pressure, body mass index, serum triglyceride, insulin resistance or blood urea nitrogen. Age and adiponectin/body fat mass (%) were negative, and blood pressure and insulin resistance were positive significant independent determinants of RBC in stepwise regression analysis. Moreover, adiponectin before and after adjustment were inversely associated with serum ALAT, gammaGTP and ChE, and positively with amylase levels (p < 0.0001 similar to 0.02). These results indicate the possibility that increased adiponectin may contribute to the suppressive bone marrow function in vivo. Combined with the leptin's data, adipocyte derived proteins were related to the hematopoiesis, therefore it has shown the possible existence of adipose tissue/bone marrow function linkage more clearly. Furthermore, hepatopancreatic enzyme associations with this protein may indicate the possibility that adiponectin will regulate the hepatopancreatic function in health and disease.