Autoimmune diseases induced by biological agents A double-edged sword?
Autoimmune diseases induced by biological agents A double-edged sword?
复制标题
DOI：
10.1016/j.autrev.2009.10.003
复制
发表时间：
2010-01-01
影响因子：
13.6
通讯作者：
Khamashta, Munther A.
中科院分区：
文献类型：
--
作者：
Ramos-Casals, Manuel;Roberto-Perez-Alvarez;Khamashta, Munther A.
生物制剂越来越多地用于快速扩大的风湿性和全身性自身免疫性疾病，越来越多的报告的矛盾诱导的自身免疫过程，压倒性地与抗TNF药物。在这篇综述中，我们通过基线Medline搜索作为BIOGEAS项目的目标之一，由西班牙内科学会创建的生物疗法后，自身免疫性疾病的临床特征和结果进行了分析。我们的登记研究的最新更新（2009年7月15日）包括800多例继发于生物治疗的自身免疫性疾病，包括各种系统性（狼疮、血管炎、结节病和抗磷脂综合征）和器官特异性（间质性肺病、葡萄膜炎、视神经炎、周围神经病变、多发性硬化和自身免疫性肝炎）自身免疫过程。大多数病例出现在开始生物制剂治疗后1个月至1年之间，在停止治疗后观察到近75%的病例完全消退。结果最差的诱发性自身免疫性疾病是间质性肺病、炎症性眼病和中枢神经系统脱髓鞘疾病。(C)2009 Elsevier B.V.保留所有权利。
Biological agents are increasingly used for a rapidly-expanding number of rheumatic and systemic autoimmune diseases, with a growing number of reports of the paradoxical induction of autoimmune processes, overwhelmingly associated with anti-TNF agents. In this review, we analyze the clinical characteristics and outcomes of autoimmune diseases developing after biological therapies through a baseline Medline search as one of the objectives of the BIOGEAS project, created by the Spanish Society of Internal Medicine. The latest update of our registry (15 July 2009) included more than 800 cases of autoimmune diseases secondary to biological therapies, including a wide variety of both systemic (lupus, vasculitis, sarcoidosis and antiphospholipid syndrome) and organ-specific (interstitial lung disease, uveitis, optic neuritis, peripheral neuropathies, multiple sclerosis and autoimmune hepatitis) autoimmune processes. The majority of cases appeared between one month and one year after initiation of the biological agent and complete resolution was observed in nearly 75% of cases after cessation of therapy. The induced autoimmune diseases with the poorest outcomes were interstitial lung disease, inflammatory ocular disease and central nervous system demyelinating diseases. (C) 2009 Elsevier B.V. All rights reserved.