A longitudinal assessment of alcohol intake and incident depression: the SUN project.
A longitudinal assessment of alcohol intake and incident depression: the SUN project.
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酒精摄入量和抑郁事件的纵向评估：SUN 项目。
DOI：
10.1186/1471-2458-12-954
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发表时间：
2012-11-07
影响因子：
4.5
通讯作者：
Beunza JJ
中科院分区：
文献类型：
--
作者：
Gea A;Martinez-Gonzalez MA;Toledo E;Sanchez-Villegas A;Bes-Rastrollo M;Nuñez-Cordoba JM;Sayon-Orea C;Beunza JJ
评估酒精摄入量和抑郁症之间长期联系的纵向研究很少。饮料的种类也很重要。因此，我们的目的是前瞻性地评估地中海队列中酒精摄入对抑郁事件的影响。我们评估了13，619名大学毕业生（平均年龄：38岁，42%男性）参与西班牙前瞻性流行病学队列（SUN项目），最初没有抑郁症。他们是在1999-2008年期间招募的，并在2001-2010年期间每两年进行一次跟踪。在基线时，使用136项经验证的食物频率问卷来评估酒精摄入量。葡萄酒是首选饮料。参与者被归类为抑郁症的事件，如果他们报告了一个新的临床诊断抑郁症的医生和/或开始使用抗抑郁药物。对82，926人-年进行了考克斯回归和限制性三次样条分析。只有在女性中，发现总酒精摄入量与抑郁风险之间存在U形关系（P=0.01）。适度饮酒（5-15 g/天）与较低风险相关（风险比：0.62; 95%置信区间：0.43-0.89）。酒精摄入量较高或任何特定类型的酒精饮料之间没有明显的联系。适量饮酒可以预防女性抑郁症。需要进一步的验证性研究。
Longitudinal studies assessing the long-term association between alcohol intake and depression are scarce. The type of beverage may also be important. Therefore we aimed to prospectively evaluate the influence of alcohol intake on incident depression in a Mediterranean cohort. We assessed 13,619 university graduates (mean age: 38 years, 42% men) participating in a Spanish prospective epidemiological cohort (the SUN Project), initially free of depression. They were recruited between 1999–2008 and biennially followed-up during 2001–2010. At baseline, a 136-item validated food–frequency questionnaire was used to assess alcohol intake. Wine was the preferred beverage. Participants were classified as incident cases of depression if they reported a new clinical diagnosis of depression by a physician and/or initiated the use of antidepressant drugs. Cox regression and restricted cubic splines analyses were performed over 82,926 person-years. Only among women, an U-shaped relationship between total alcohol intake and depression risk was found (P=0.01). Moderate alcohol intake (5–15 g/day) was associated with lower risk (Hazard Ratio: 0.62; 95% Confidence Interval: 0.43-0.89). No association was apparent for higher intakes of alcohol or for any specific type of alcoholic beverage. Moderate alcohol intake might protect against depression among women. Further confirmatory studies are needed.
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影响因子：
3.2
作者：
Martínez-González, MA;López-Fontana, C;Martinez, JA
通讯作者：
Martinez, JA
影响因子：
5.4
作者：
GREENLAND, S
通讯作者：
GREENLAND, S
DOI：
10.1111/j.1530-0277.2006.00274.x
发表时间：
2007-01-01
影响因子：
3.2
作者：
Graham, Kathryn;Massak, Agnes;Rehm, Juergen
通讯作者：
Rehm, Juergen
DOI：
10.1093/jurban/79.3.373
发表时间：
2002-09-01
影响因子：
6.6
作者：
Armenian, HK;Morikawa, M;Akiskal, HS
通讯作者：
Akiskal, HS
影响因子：
6.6
作者：
Ogasawara, Kazuyoshi;Nakamura, Yukako;Ozaki, Norio
通讯作者：
Ozaki, Norio