ACE inhibition salvages the visual loss caused by diabetes
ACE inhibition salvages the visual loss caused by diabetes
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DOI：
10.1007/s00125-003-1042-7
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发表时间：
2003-03-01
期刊：
影响因子：
8.2
通讯作者：
Vingrys, AJ
中科院分区：
文献类型：
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作者：
Bui, BV;Armitage, JA;Vingrys, AJ
目标。我们考虑链脲佐菌素大鼠视网膜功能障碍的性质，并评估给予血管紧张素酶抑制剂或晚期糖基化终产物形成抑制剂的功能益处。方法。 Sprague-Dawley 大鼠 (n=44) 被随机分配至对照组 (C=12、C-p=4、C-a=4) 和糖尿病组 (链脲佐菌素，D=24)。根据第 4、8 和 12 周时的一系列生理和生化参数诊断糖尿病。每天给动物链脲佐菌素注射胰岛素（4单位原烷）。用血管紧张素转换酶抑制剂（培哚普利，C-p=4 D-p=8）或晚期糖基化终产物信息抑制剂（氨基胍，C-a=4，D-a=8）治疗动物。在链脲佐菌素治疗后 12 周，对麻醉动物进行暗适应视网膜电图测量。使用方差分析提取、建模和比较感光和视网膜内部反应。结果。注射链脲佐菌素会增加血糖、糖化血红蛋白、液体摄入量和尿量，而体重却下降。培哚普利治疗产生了改善（p
Aims. We consider the nature of retinal dysfunction in streptozotocin rats and assess the functional benefits of administering an angiotensin enzyme inhibitor or an inhibitor of advanced glycation end product formation.Methods. Sprague-Dawley rats (n=44) were randomly assigned to control (C=12, C-p=4, C-a=4) and diabetic groups (Streptozotocin, D=24). Diabetes was diagnosed based on a range of physiological and biochemical parameters at 4, 8 and 12 weeks. Streptozotocin animals were administered insulin daily (4 units protophane). Animals were treated with either an Angiotensin Converting Enzyme inhibitor (perindopril, C-p=4 D-p=8) or an inhibitor of advanced glycation end product information (aminoguanidine, C-a=4, D-a=8). Dark-adapted electroretinograms were measured on anaesthetized animals at 12 weeks following streptozotocin treatment. Photoreceptoral and inner retinal responses were extracted, modelled and compared using ANOVA.Results. Streptozotocin injection increased blood glucose, glycosylated haemoglobin, fluid intake and urine volume, whereas body weight was decreased. Perindopril treatment produced improvements (p