Increased urinary levels of pentosidine, pyrraline and acrolein adduct in type 2 diabetes
Increased urinary levels of pentosidine, pyrraline and acrolein adduct in type 2 diabetes
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DOI：
10.1507/endocrj.50.61
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发表时间：
2003-02-01
影响因子：
2
通讯作者：
Kato, T
中科院分区：
文献类型：
--
作者：
Daimon, M;Sugiyama, K;Kato, T
本研究旨在探讨2型糖尿病（DM）患者尿中戊糖苷、吡咯啉和丙烯醛加合物水平是否升高，以及这些水平是否与血糖控制和临床特征相关。从我们大学医院门诊招募的糖尿病患者（n = 100）与年龄和性别匹配的非糖尿病受试者（n = 50）的尿戊糖苷，吡咯啉和丙烯醛加合物的水平进行了比较。并对这些指标与血糖控制及临床特征的相关性进行了研究。此外，吸烟习惯对丙烯醛加合物水平的影响进行了研究。尿戊糖苷、吡咯啉和丙烯醛加合物水平均显著高于对照组（P
This study investigates whether urinary levels of pentosidine, pyrraline and acrolein adduct are increased in type 2 diabetes (DM), and whether these levels are correlated with glycemic control and clinical traits. Urinary levels of pentosidine, pyrraline and acrolein adduct in DM patients (n = 100) recruited from the outpatient clinic of our university hospital were compared with those of age- and sex-matched non-diabetic subjects (n = 50). The correlation of these urinary levels with the glycemic control and the clinical traits were examined. Furthermore, the influence of smoking habit on the levels of acrolein adduct was examined. Urinary levels of pentosidine, pyrraline and acrolein adduct were all significantly (p