Are voltage-gated sodium channels on the dorsal root ganglion involved in the development of neuropathic pain?
Are voltage-gated sodium channels on the dorsal root ganglion involved in the development of neuropathic pain?
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DOI：
10.1186/1744-8069-7-16
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发表时间：
2011-02-23
期刊：
影响因子：
3.3
通讯作者：
Tao YX
中科院分区：
文献类型：
--
作者：
Wang W;Gu J;Li YQ;Tao YX
神经性疼痛是一种常见的临床症状。目前的治疗方法往往不充分、无效或产生潜在的严重副作用。了解神经性疼痛发展和维持的机制将有助于确定新的治疗靶点和制定预防和/或治疗这种疾病的有效策略。神经性疼痛的发生至少部分依赖于感觉神经元的异常自发活动。因此，对动作电位的产生和传导至关重要的电压门控钠通道是治疗神经性疼痛的潜在靶点。然而，临床前研究显示了意想不到的结果，因为周围神经损伤后，背根神经节中大多数与疼痛相关的电压门控通道被下调。背根神经节电压门控通道在神经性疼痛中的作用尚不清楚。在本报告中，我们描述了电压门控钠通道在背根神经节中的表达和分布。我们还回顾了它们在神经性疼痛条件下表达变化的证据，以及它们在各种神经性疼痛模型中的行为反应中的作用。我们最后讨论了它们与神经性疼痛的潜在关系。
Neuropathic pain is a common clinical condition. Current treatments are often inadequate, ineffective, or produce potentially severe adverse effects. Understanding the mechanisms that underlie the development and maintenance of neuropathic pain will be helpful in identifying new therapeutic targets and developing effective strategies for the prevention and/or treatment of this disorder. The genesis of neuropathic pain is reliant, at least in part, on abnormal spontaneous activity within sensory neurons. Therefore, voltage-gated sodium channels, which are essential for the generation and conduction of action potentials, are potential targets for treating neuropathic pain. However, preclinical studies have shown unexpected results because most pain-associated voltage-gated channels in the dorsal root ganglion are down-regulated after peripheral nerve injury. The role of dorsal root ganglion voltage-gated channels in neuropathic pain is still unclear. In this report, we describe the expression and distribution of voltage-gated sodium channels in the dorsal root ganglion. We also review evidence regarding changes in their expression under neuropathic pain conditions and their roles in behavioral responses in a variety of neuropathic pain models. We finally discuss their potential involvement in neuropathic pain.
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影响因子：
3
作者：
Bird, E. V.;Robinson, P. P.;Boissonade, F. M.
通讯作者：
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影响因子：
4
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DOI：
10.1073/pnas.95.15.8963
发表时间：
1998-07-21
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
2.5
作者：
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